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Screening Procedures Based in Modified Classification Trees Applied to Paediatric Familial Hypercholesterolemia

2018-06Conference object Restricted access
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dc.contributor.authorAlbuquerque, João
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorAntunes, Marília
dc.date.accessioned2018-09-26T15:48:44Z
dc.date.available2018-09-26T15:48:44Z
dc.date.issued2018-06
dc.descriptionThe research by João Albuquerque was supported by the programmme Norte2020 (operação NORTE-08-5369-FSE-000018); The research by Marília Antunes was supported by national funds through FCT under the project UID/MAT/00006/2013.pt_PT
dc.description.abstractIntroduction: Familial Hypercholesterolemia (FH) is a monogenic disorder of lipid metabolism, resulting in severe dyslipidemia and increased risk of cardiovascular disease. Simon Broome (SB) criteria for the diagnostic of FH are among the most frequently used in clinical setting, and are based on elevated total (CT) and low density lipoprotein (LDL-c) cholesterol levels, presence of tendinous xanthomas and family history, although only genetic testing can confirm the diagnostic. The main purpose of this work was to develop an alternative classification model for FH based on a modified version of the classic decision tree (DT), using several biochemical indicators as predictor variables: CT, LDL-c, high density lipoprotein cholesterol (HDL-c) and triglycerides (TG) concentrations. The DT model was fitted to sample data, and correspondent operating characteristics were compared to the ones obtained with the biochemical indicators used in SB criteria, through bootstrap resampling techniques.
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5611
dc.language.isoengpt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpt_PT
dc.subjectFamilial Hypercholesterolemiapt_PT
dc.subjectDyslipidemiapt_PT
dc.subjectDecision Treespt_PT
dc.subjectSimon Broome Criteria
dc.subjectOperating Characteristics
dc.subjectDoenças Cardio e Cérebro-vasculares
dc.subjectHipercolesterolemia Familiar
dc.titleScreening Procedures Based in Modified Classification Trees Applied to Paediatric Familial Hypercholesterolemiapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceAveiro, Portugalpt_PT
oaire.citation.titleIII Encontro Luso-Galaico de Biometria (EBio2018), 28-30 Junho 2018.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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