Publicação
Predicted no effect concentrations of antifungals for wastewater management and agricultural use
| dc.contributor.author | Gil, D. | |
| dc.contributor.author | José, S. | |
| dc.contributor.author | Ascenso, A. | |
| dc.contributor.author | Babič, M. Novak | |
| dc.contributor.author | Segal, E. | |
| dc.contributor.author | Meletiadis, J. | |
| dc.contributor.author | Gangneux, J.P. | |
| dc.contributor.author | Weiskerger, C.J. | |
| dc.contributor.author | Solo-Gabriele, H.M. | |
| dc.contributor.author | Valério, E. | |
| dc.contributor.author | Brandão, J. | |
| dc.date.accessioned | 2026-04-15T10:43:55Z | |
| dc.date.available | 2026-04-15T10:43:55Z | |
| dc.date.issued | 2026-03-24 | |
| dc.description.abstract | Antifungal resistance is an on-growing public health concern due to the difficulty in managing or treating medical conditions that often favour fatal fungal infections. The changing climate and globalisation, which increase fungal persistence and propagation, adds to that concern. Wastewater disposal is one potential source to the environment as antifungals are released into it. Considering that most fungal infections originate from the environment and considering the One Health principle, introducing antifungals through wastewater effluents has the potential to promote the emergence and dissemination of antifungal resistance. The objective of this study was to generate knowledge that can assist regulating the release of antifungals in the environment by quantifying predicted no-effect concentrations (PNECs) that would not promote antifungal resistance. For this purpose, a systematic review was performed to consolidate information on antifungals released to the environment and respective concentrations. The systematic literature review followed Preferred Reporting Items for Systematic literature reviews and Meta Analyses extension for Scoping Reviews (PRISMA-SLR). The analysis of 122 reviewed articles using this approach showed high concentrations and dispersion of antifungals in water, wastewater or soil. This highlights their potential dispersion in the environment, thus increasing the potential of fungal antimicrobial resistance. Due to the lack of PNEC values using fungi as model organisms in this review, PNECs for 17 antifungals were calculated using as model, as it is done for clinical purposes. We consider that the antifungal PNECs calculated and consolidated from the literature can be used to prioritise them for regulation and to determine acceptable levels in wastewater effluents. | eng |
| dc.description.sponsorship | This work was funded by Fundação para a Ciência e Tecnologia (FCT) through CE3C - Centre for Ecology, Evolution and Environmental Changes unit funding (UIDB/00329/2025) and CHANGE LA/P/0121/2020, (https://doi.org/10.54499/LA/P/0121/2020). Monika Novak Babič was supported through the Slovenian Research and Innovation Agency (ARIS) to Infrastructural Centre Mycosmo (MRIC UL, I0-0022), and research program, grant number P1-0198. She also received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101185862. | |
| dc.identifier.citation | Front Toxicol. 2026 Mar 24:8:1767925. doi: 10.3389/ftox.2026.1767925. eCollection 2026. Review | |
| dc.identifier.doi | 10.3389/ftox.2026.1767925 | |
| dc.identifier.eissn | 2673-3080 | |
| dc.identifier.eissn | 2673-3080 | |
| dc.identifier.pmid | 41953278 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/11302 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Frontiers Media | |
| dc.relation | Archibiome tattoo for resistant, responsive, and resilient cities | |
| dc.relation | LA/P/0121/2020 | |
| dc.relation | UIDB/00329/2025 | |
| dc.relation.hasversion | https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1767925/full | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | One Health | |
| dc.subject | PNEC | |
| dc.subject | Antifungal Resistance | |
| dc.subject | Antifungals Dispersion in Environment | |
| dc.subject | Systematic Literature Reviews | |
| dc.subject | Wastewater | |
| dc.subject | Resistência aos Antimicrobianos | |
| dc.subject | Agentes Microbianos e Ambiente | |
| dc.subject | Água e Solo | |
| dc.title | Predicted no effect concentrations of antifungals for wastewater management and agricultural use | eng |
| dc.type | journal article | |
| dcterms.references | https://www.frontiersin.org/articles/10.3389/ftox.2026.1767925/full#supplementary-material | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | 101185862 | |
| oaire.awardTitle | Archibiome tattoo for resistant, responsive, and resilient cities | |
| oaire.awardURI | http://hdl.handle.net/10400.18/11301 | |
| oaire.citation.startPage | 1767925 | |
| oaire.citation.title | Frontiers in Toxicology | |
| oaire.citation.volume | 8 | |
| oaire.fundingStream | HORIZON EIC Grants | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| relation.isProjectOfPublication | 4a9b069f-4cd6-4ac2-81e4-6d1d3ee26fb8 | |
| relation.isProjectOfPublication.latestForDiscovery | 4a9b069f-4cd6-4ac2-81e4-6d1d3ee26fb8 |