Publication
Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis
| dc.contributor.author | David, Susana | |
| dc.contributor.author | Mateus, A.R.A. | |
| dc.contributor.author | Duarte, Elsa | |
| dc.contributor.author | Albuquerque, José Maria | |
| dc.contributor.author | Portugal, Clara | |
| dc.contributor.author | Sancho, Luísa | |
| dc.contributor.author | Lavinha, João | |
| dc.contributor.author | Gonçalves, Guilherme | |
| dc.date.accessioned | 2016-03-04T15:55:22Z | |
| dc.date.available | 2016-03-04T15:55:22Z | |
| dc.date.issued | 2015-11-03 | |
| dc.description.abstract | Major contributions from pathogen genome analysis and host genetics have equated the possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more stable sympatric host–pathogen relationships. However, the attribution to either sympatric or allopatric categories depends on the resolution or grain of genotypic haracterization. We explored the influence on the sympatric host-pathogen relationship of clinical (HIV infection and multidrug-resistant tuberculosis [MDRTB]) and demographic (gender and age) factors in regards to the genotypic grain by using spacer oligonucleotide typing (spoligotyping) for classification of M. tuberculosis strains within the Euro-American lineage. We analyzed a total of 547 tuberculosis (TB) cases, from six year consecutive sampling in a setting with high TB-HIV coinfection (32.0%). Of these, 62.0% were caused by major circulating pathogen genotypes. The sympatric relationship was defined according to spoligotype in comparison to the international spoligotype database SpolDB4. While no significant association with Euro-American lineage was observed with any of the factors analyzed, increasing the resolution with spoligotyping evidenced a significant association of MDRTB with sympatric strains, regardless of the HIV status. Furthermore, distribution curves of theprevalence of sympatric and allopatric TB in relation to patients’ age showed an accentuation of the relevance of the age of onset in the allopatric relationship, as reflected in the trimodal distribution. On the contrary, sympatric TB was characterized by the tendency towards a typical (standard) distribution curve. Our results suggest that within the EuroAmerican lineage a greater degree of genotyping fine-tuning is necessary in modeling the biological processes behind the host-pathogen interplay. Furthermore, prevalence distribution of sympatric TB to age was suggestive of host genetic determinisms driven by more common variants | pt_PT |
| dc.description.sponsorship | : This work was supported by the LusoAmerican Development Foundation (LACR Award program - 2007) and the Fundação para a Ciencia e Tecnologia (FCT), Portugal, (grant reference: POCTI/ ESP/44826/2002), coparticipated by the European Community fund FEDER. | pt_PT |
| dc.identifier.citation | PLoS One. 2015 Nov 3;10(11):e0140625. doi: 10.1371/journal.pone.0140625. eCollection 2015. | pt_PT |
| dc.identifier.doi | 10.137/journal.pone.0140625 | pt_PT |
| dc.identifier.issn | 1932-6203 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/3654 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Public Library of Science | pt_PT |
| dc.relation | Search for inhibitors of the D-ala-D-ala pathway in peptidoglycan synthesis as potential anti-tuberculosis drugs | |
| dc.relation.publisherversion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140625 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Tuberculosis | pt_PT |
| dc.subject | Susceptibilidade à Infeção | pt_PT |
| dc.subject | Mycobacterium tuberculosis | pt_PT |
| dc.subject | Host-pathogen interactions | pt_PT |
| dc.subject | HIV infections | pt_PT |
| dc.subject | Phylogeography | pt_PT |
| dc.subject | Age groups | pt_PT |
| dc.subject | HIV | pt_PT |
| dc.subject | Infecções Respiratórias | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.subject | Portugal | pt_PT |
| dc.title | Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Search for inhibitors of the D-ala-D-ala pathway in peptidoglycan synthesis as potential anti-tuberculosis drugs | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCTI%2FESP%2F44826%2F2002/PT | |
| oaire.citation.endPage | 18 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | PLoS One | pt_PT |
| oaire.citation.volume | 10(11) | pt_PT |
| oaire.fundingStream | POCI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 3d2dc33e-924e-40d5-bc9d-1a34056f8d22 | |
| relation.isProjectOfPublication.latestForDiscovery | 3d2dc33e-924e-40d5-bc9d-1a34056f8d22 |