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Improving risk assessment of chemicals by the use of human biomonitoring - HBM4EU project activities

2017-10-02Conference object Restricted access
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dc.contributor.authorSantonen, T.
dc.contributor.authorAlvito, Paula
dc.contributor.authorBessems, J.
dc.contributor.authorBorges, T.
dc.contributor.authorBrunet, D.
dc.contributor.authorBuekers, J.
dc.contributor.authorCornelis, C.
dc.contributor.authorvan Engelen, J.
dc.contributor.authorGonzalez Caballero, M.C.
dc.contributor.authorHumar-Juric, T.
dc.contributor.authorHeinälä, M.
dc.contributor.authorKlaus, A.
dc.contributor.authorKononenko, L.
dc.contributor.authorKrul, L.
dc.contributor.authorLamkarkach, F.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorPronk, A.
dc.contributor.authorOrmsby, J-N.
dc.contributor.authorViegas, S.
dc.contributor.authorRousselle, C.
dc.contributor.authorSchaddelee-Scholten, B.
dc.contributor.authorSilva, Maria João
dc.contributor.authorStierum, R.
dc.contributor.authorVinggaard, S A.M.
dc.contributor.authorVermeire, T.
dc.contributor.authorWoutersen, M.
dc.date.accessioned2018-02-20T12:49:31Z
dc.date.available2018-02-20T12:49:31Z
dc.date.issued2017-10-02
dc.description.abstractThe default approach in the risk assessment (RA) of chemicals is to assess external exposure by combining different sources and routes of exposure. This kind of approach contains various uncertainties and may overestimate exposure, since conservative estimates are needed due to the limited data on, for example, the absorption of the chemical and interspecies and intraspecies differences. Human biomonitoring (HBM) can help improve RA by providing measured data on combined exposures. In some cases, biomonitoring data can even provide a direct link to health effects. In some cases, biomonitoring allows to link exposure to specific contexts such as occupational settings. Although recent years have seen good examples of the use of biomonitoring in the risk assessment of chemicals, much work is still needed to improve its use in regulatory RA and human impact assessment (HIA). The European Human Biomonitoring Initiative (HBM4EU) was recently launched for fulfilling the gap between the exposure to hazardous chemical agents and their impact on human health. One of the aims of the HBM4EU project is to enhance the use of HBM data in RA and HIA of chemicals in different regulatory contexts including legislations on chemicals, plant protection products and biocides, as well as legislation on cosmetics, food safety and occupational safety. RA models for mixtures are also considered. Firstly, current RA practices are evaluated: is the use of biomonitoring integrated in the available RA guidance, and do given RA schemes have good examples of the advanced use of biomonitoring? A survey is also conducted to gather information from national regulatory risk assessors (in the EU, but also in non-EU countries) on their risk assessment practices, the use of HBM, and the obstacles and challenges related to its use. The challenges of the use of HBM data in RA may include a lack of guidance in the use of biomonitoring, a lack of knowledge regarding the interpretation of biomonitoring results, or the inability to link biomonitoring data to different exposure sources. Using a selected group of priority chemicals as example, we can determine whether these challenges can be overcome by including the recent HBM data, collected during the HBM4EU project, in the existing RA schemes. Finally, proposals will be made for the better use of HBM in RA and HIA in different policy domains.pt_PT
dc.description.sponsorshipHBM4EU project, Grant agreement No: 733032pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4995
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.titleImproving risk assessment of chemicals by the use of human biomonitoring - HBM4EU project activitiespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceNaples, Itáliapt_PT
oaire.citation.title10th International Symposium on Biological Monitoring (ISBM-10), 2-4 October 2017pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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