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Study on cellulose nanofibrils biological effects in different cellular models

2020-11-15Conference object Restricted access
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dc.contributor.authorPinto, Fátima
dc.contributor.authorVentura, Célia
dc.contributor.authorTeixeira, Sara
dc.contributor.authorVilar, Madalena
dc.contributor.authorLourenço, Ana Filipa
dc.contributor.authorFerreira, Paulo J.T.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2021-03-13T15:42:18Z
dc.date.available2021-03-13T15:42:18Z
dc.date.issued2020-11-15
dc.description.abstractCellulose nanofibrils (CNFs), is an innovative environmental friendly material that has been incorporated into several types of materials, in both pure and composite forms and holds great promise in different fields of application. This leads to a rising level of human exposure and draws considerable concerns regarding its potential toxicity in humans, which are specially motivated by the physicochemical resemblance of cellulose nanofibrils with multi-walled carbon nanotubes and asbestos that have shown deleterious health effects. Currently, several in vitro toxicological studies have been performed with the aim of predicting health effects caused by exposure to CNFs. A literature review was performed to gather and analyse recent data regarding the potential cytotoxic, genotoxic, immunotoxic and epigenetic effects, in different in vitro cell models, triggered by the exposure to CNFs produced from vegetal biomass and consequently differing in critical physicochemical characteristics. The main findings of this review work demonstrate that different functionalization affects CNFs hydrophobicity, surface charge and chemistry, which may either facilitate or difficult the uptake and interaction of its functional groups with the cell membrane, affecting the biological responses. Generally, CNFs are not phagocytized and do not cause inflammatory response, but revealed in vitro genotoxicity. In fact, our data have shown that CNFs may induce chromosome damage in some cell models, e.g., a co-culture of epithelial lung alveolar cells and macrophages. However, more studies are required to assess CNFs toxicity and to understand the relationship between their physicochemical properties, their behaviour in biological media and mechanism of action, which are of outmost importance to predict their nanosafety.pt_PT
dc.description.sponsorshipThe authors acknowledge CYTED network NANOCELIA (Transferencia Tecnológica sobre aplicaciones de nanocelulosa en iberoame´rica). The work was funded by FCT/MCTES, Project ToxApp4NanoCELFI (PTDC/ SAU-PUB/32587/2017) through national funds (PIDDAC) and co-funded by ToxOmics – Center for Toxicogenomics and Human Health (UID/BIM/00009/2013). Sara Teixeira is acknowledged for the binucleated cells photo.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7449
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.subjectCellulose Nanofibrilspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleStudy on cellulose nanofibrils biological effects in different cellular modelspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title2nd International Online-Conference on Nanomaterials (IOCN), 15-30 November 2020pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameVentura
person.familyNameLouro
person.familyNameSilva
person.givenNameCélia
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier2056460
person.identifier157627
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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