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The Sensitivity and Resistance of Yeasts Isolated from Women with Vulvovaginal Candidiasis to Common Antifungal drugs Using Disc Diffusion

2010-06Journal article Open access
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dc.contributor.authorMoallaie, Hossein
dc.contributor.authorVerissimo, Cristina
dc.contributor.authorBrandão, João
dc.contributor.authorRosado, Laura
dc.date.accessioned2011-09-17T08:35:41Z
dc.date.available2011-09-17T08:35:41Z
dc.date.issued2010-06
dc.description.abstractBackground and Purpose: Due to the ever-increasing use of antifungal drugs especially those of azole group, the prevalence of recurrent forms of vaginal infections and the number of drug-resistant yeasts are on the rise. Therefore, the rpesent study is conducted to investigate the sensitivity and resistance of yeasts isolated from vaginal infections to antifungal drugs. Methods and Materials: This cross-sectional descriptive analytical study was conducted on 118 yeasts isolated from 436 suspects of vulvovaginal candidiasis; their sensitivity and resisitance to drugs belonging to imidazoles group including clotrimazole (CTR), fluconazole (FCA), ketoconazole (KET), miconazole (MCZ) and econazole (EC) as well as nystatine (NY) belonging to polyene group using the standard disc diffusion technique. To determine their relationship clinical symptoms and the raltion of resistance to one drug with resistance to other drugs, relevant tests were used including chi-square, kappa and linear regression coefficient in SPSS 11. Results: The results showed no resistance to nystatine from polyene group and econazole from azole group; however, 53 cases (%44.9) were resistant to fluconazole, 26 cases (%22) to miconazole, 10 cases (%8.5) to clotrimazole and 2 cases (%1.7) to ketoconazole. Conclusion: The results of linear correlation showed a negative correlation between the sensitivity of yeasts to CTR and KET and clinical symptoms.por
dc.identifier.citationJournal of Sabzevar School of Medical Sciences 2010 Winter; 16(4 (54)):213-219por
dc.identifier.issn1606-7487
dc.identifier.urihttp://hdl.handle.net/10400.18/187
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSabzevar University of Medical Sciencespor
dc.relation.publisherversionhttp://jssms.hbi.ir/library/upload/article/af_24352656-Moallaee.pdfpor
dc.subjectImidazole drugspor
dc.subjectDrug resistancepor
dc.subjectVulvovaginal candidiasispor
dc.subjectInfecções Sistémicas e Zoonosespor
dc.titleThe Sensitivity and Resistance of Yeasts Isolated from Women with Vulvovaginal Candidiasis to Common Antifungal drugs Using Disc Diffusionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage219por
oaire.citation.startPage213por
oaire.citation.titleJournal of Sabzevar School of Medical Sciencespor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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