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Refractory myasthenia gravis: Characteristics of a portuguese cohort

2019-05-15Journal article Restricted access
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dc.contributor.authorSantos, Ernestina
dc.contributor.authorBettencourt, Andreia
dc.contributor.authorDuarte, Sara
dc.contributor.authorGabriel, Denis
dc.contributor.authorOliveira, Vanessa
dc.contributor.authorda Silva, Ana Martins
dc.contributor.authorCosta, Paulo Pinho
dc.contributor.authorLopes, Carlos
dc.contributor.authorGonçalves, Guilherme
dc.contributor.authorda Silva, Berta Martins
dc.contributor.authorLeite, Maria Isabel
dc.date.accessioned2020-05-11T09:32:47Z
dc.date.available2020-05-11T09:32:47Z
dc.date.issued2019-05-15
dc.description.abstractIntroduction: Some myasthenia gravis (MG) patients are refractory to conventional treatments. Methods: To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria. Results: Twenty-two patients were found to have RMG (19.3%). There were no differences between non-RMG and RMG patients with respect to sex, age of onset, abnormal 3-Hz repetitive nerve stimulation, anti-acetylcholine receptor antibody positivity, thymectomy, thymoma or thymic hyperplasia, and polyautoimmunity. HLA-DRB1*03 was more frequent in the non-RMG vs. control population (P = 3 × 10-6 ). The HLA-DRB1*13 allele was less frequent in non-RMG patients compared with controls (P = 0.002), and less frequent in the non-RMG group compared with the RMG group (P = 0.003). Discussion: HLA-DRB1*03 was more common in non-RMG, and the HLA-DRB1*13 allele appeared to have a protective role, as reported previously in other autoimmune disorders. Muscle Nerve 60: 188-191, 2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMuscle Nerve. 2019 Aug;60(2):188-191. doi: 10.1002/mus.26507. Epub 2019 May 15pt_PT
dc.identifier.doi10.1002/mus.26507pt_PT
dc.identifier.issn0148-639X
dc.identifier.urihttp://hdl.handle.net/10400.18/6648
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley Periodicalspt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mus.26507pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdultpt_PT
dc.subjectAge of Onsetpt_PT
dc.subjectAutoantibodiespt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectCohort Studiespt_PT
dc.subjectFemalept_PT
dc.subjectGenetic Predisposition to Diseasept_PT
dc.subjectHLA-DRB1 Chainspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMyasthenia Gravispt_PT
dc.subjectPortugalpt_PT
dc.subjectProtective Factorspt_PT
dc.subjectReceptors, Cholinergicpt_PT
dc.subjectThymectomypt_PT
dc.subjectThymomapt_PT
dc.subjectThymus Hyperplasiapt_PT
dc.subjectThymus Neoplasmspt_PT
dc.subjectYoung Adultpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleRefractory myasthenia gravis: Characteristics of a portuguese cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage191pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage188pt_PT
oaire.citation.titleMuscle and Nervept_PT
oaire.citation.volume60pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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