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Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study

2020-06-24Journal article Restricted access
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dc.contributor.authorGoldsmith, Shona
dc.contributor.authorMcintyre, Sarah
dc.contributor.authorAndersen, Guro L
dc.contributor.authorGibson, Catherine
dc.contributor.authorHimmelmann, Kate
dc.contributor.authorBlair, Eve
dc.contributor.authorBadawi, Nadia
dc.contributor.authorSmithers‐Sheedy, Hayley
dc.contributor.authorGarne, Ester
dc.contributor.authorComprehensive CA-CP Study Group
dc.date.accessioned2021-03-06T16:18:13Z
dc.date.available2021-03-06T16:18:13Z
dc.date.issued2020-06-24
dc.descriptionMembers of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSApt_PT
dc.description.abstractAim: To describe the frequency and types of major congenital anomalies present in children with pre- or perinatally acquired cerebral palsy (CP), and compare clinical outcomes for children with and without anomalies. Method: This multi-centre total population collaborative study between Surveillance of Cerebral Palsy in Europe, Australian Cerebral Palsy Register, and European Surveillance of Congenital Anomalies (EUROCAT) involved six European and three Australian regions. Data were linked between each region's CP and congenital anomaly register for children born between 1991 and 2009, and then pooled. Children were classified into mutually exclusive categories based on type of anomaly. Proportions of children with congenital anomalies were calculated, and clinical outcomes compared between children with and without anomalies. Results: Of 8201 children with CP, 22.8% (95% confidence interval [CI] 21.9, 23.8) had a major congenital anomaly. Isolated cerebral anomalies were most common (45.2%), with a further 8.6% having both cerebral and non-cerebral anomalies. Cardiac anomalies only were described in 10.5% of children and anomalies associated with syndromes were also reported: genetic (8.0%), chromosomal (5.7%), and teratogenic (3.0%). Clinical outcomes were more severe for children with CP and congenital anomalies, particularly cerebral anomalies. Interpretation: This large, international study reports major congenital anomalies in nearly one-quarter of children with pre- or perinatally acquired CP. Future research must focus on aetiological pathways to CP that include specific patterns of congenital anomalies. What this paper adds: Congenital anomalies were reported in 23% of children with pre- or perinatally acquired cerebral palsy. A higher proportion of children born at or near term had anomalies. The most common type of anomalies were isolated cerebral anomalies. Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral).pt_PT
dc.description.sponsorshipCerebral Palsy Alliance Research Foundation. Grant Numbers: PG1215, PG2816, Salary support (SG, SM, HSS, NB)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDev Med Child Neurol. 2021 Apr;63(4):413-420. doi: 10.1111/dmcn.14602. Epub 2020 Jun 24.pt_PT
dc.identifier.doi10.1111/dmcn.14602pt_PT
dc.identifier.issn0012-1622
dc.identifier.urihttp://hdl.handle.net/10400.18/7349
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley/ Mac Keith Presspt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/dmcn.14602pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCongenital Anomaliespt_PT
dc.subjectChildrenpt_PT
dc.subjectEuropean Surveillance of Congenital Anomaliespt_PT
dc.subjectEUROCATpt_PT
dc.subjectAnomalias Congénitaspt_PT
dc.subjectParalisia Cerebralpt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectRegistos Epidemiológicospt_PT
dc.subjectRegisto Nacional de Anomalias Congénitaspt_PT
dc.subjectRENACpt_PT
dc.subjectPrograma Nacional de Vigilância da Paralisia Cerebralpt_PT
dc.subjectPNVPCpt_PT
dc.subjectEuropept_PT
dc.subjectPortugalpt_PT
dc.titleCongenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage420pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage413pt_PT
oaire.citation.titleDevelopmental Medicine and Child Neurologypt_PT
oaire.citation.volume63pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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