Publication
Stroma cell-derived signals stimulate expression of tumor-promoting RAC1B in colorectal cells
| dc.contributor.author | Pereira, Joana | |
| dc.contributor.author | Matos, Paulo | |
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2018-03-05T18:30:56Z | |
| dc.date.available | 2018-03-05T18:30:56Z | |
| dc.date.issued | 2017-06-01 | |
| dc.description.abstract | An inflammatory microenvironment is a tumor-promoting condition that provides survival signals to which cancer cells respond with changes in their gene expression. One key gene regulatory mechanism that responds to extracellular signals is alternative splicing. For example RAC1B, a RAC1 alternative splicing variant that we previously identified in a subset of BRAF-mutated colorectal tumours, was found increased in samples from inflammatory bowel disease patients or following experimentally-induced acute colitis in a mouse model. The main goal of this work is to determine the pro-inflammatory signals that lead to increased RAC1B expression in colorectal cells. | pt_PT |
| dc.description.sponsorship | Funding Suport: fellowship BRJ-DGH 2012_oncologia from INSA; grant UID/MULTI/04046/2013 and SFRH/BD/109162/2015 from FCT | pt_PT |
| dc.description.version | info:eu-repo/semantics/draft | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5197 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.subject | cancro coloretal | pt_PT |
| dc.subject | RAC1b | pt_PT |
| dc.subject | splicing alternativo | pt_PT |
| dc.title | Stroma cell-derived signals stimulate expression of tumor-promoting RAC1B in colorectal cells | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/WT/Genetic & Molecular Sciences/109162 | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | SINAL 2017- 8th international meeting on signal transduction, 1-2 junho 2017 | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | Genetic & Molecular Sciences | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/100010269 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Wellcome Trust | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication | 540185ab-214e-4848-8df9-1490caeacb8c | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |