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Publicação
Targeting the serrated pathway of colorectal cancer with mutation in BRAF
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Orientador(es)
Resumo(s)
A recently acknowledged morphological pathway to colorectal cancer originates from precursor polyps with a serrated appearance due to branching and folding of the colon epithelium. This serrated origin accounts for up to 30% of all colorectal tumors but these are heterogeneous regarding molecular characteristics and patient outcome. Here we review the current knowledge about the classification of this tumor subtype and its association with five key features: mutation status of the BRAF or KRAS genes, the CpG island methylation phenotype, microsatellite instability, immune cell infiltration, and overexpression of GTPase RAC1b. Subsequently, available therapeutic approaches for targeting these molecular characteristics are presented and critically discussed.
Descrição
Palavras-chave
Vias de Transdução de Sinal e Patologias Associadas Colorectal Cancer BRAF RAC1b Serrated Pathway
Contexto Educativo
Citação
Biochim Biophys Acta. 2016 Aug;1866(1):51-63. doi: 10.1016/j.bbcan.2016.06.003. Epub 2016 Jun 21.
Editora
Elsevier