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A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles

2021-09-25Journal article Open access
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dc.contributor.authorZare Jeddi, Maryam
dc.contributor.authorVirgolino, Ana
dc.contributor.authorFantke, Peter
dc.contributor.authorHopf, Nancy B.
dc.contributor.authorGalea, Karen S.
dc.contributor.authorRemy, Sylvie
dc.contributor.authorViegas, Susana
dc.contributor.authorMustieles, Vicente
dc.contributor.authorFernandez, Mariana F.
dc.contributor.authorvon Goetz, Natalie
dc.contributor.authorVicente, Joana Lobo
dc.contributor.authorSlobodnik, Jaroslav
dc.contributor.authorRambaud, Loïc
dc.contributor.authorDenys, Sébastien
dc.contributor.authorSt-Amand, Annie
dc.contributor.authorNakayama, Shoji F.
dc.contributor.authorSantonen, Tiina
dc.contributor.authorBarouki, Robert
dc.contributor.authorPasanen-Kase, Robert
dc.contributor.authorMol, Hans G.J.
dc.contributor.authorVermeire, Theo
dc.contributor.authorJones, Kate
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorvan der Voet, Hilko
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorVerhagen, Hans
dc.contributor.authorCanova, Cristina
dc.contributor.authorvan Klaveren, Jacob
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorBessems, Jos
dc.date.accessioned2021-10-18T11:55:10Z
dc.date.available2021-10-18T11:55:10Z
dc.date.issued2021-09-25
dc.description.abstractData generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data. It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2021 Sep 25;238:113826. doi: 10.1016/j.ijheh.2021.113826. Online ahead of print.pt_PT
dc.identifier.doi10.1016/j.ijheh.2021.113826pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/7784
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Urban and Fischerpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463921001413?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectRegulatory Risk Assessmentpt_PT
dc.subjectRegistrypt_PT
dc.subjectData Governancept_PT
dc.subjectData Value Chainpt_PT
dc.subjectHarmonisationpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleA human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage113826pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume238pt_PT
person.familyNameSilva
person.familyNameLouro
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242

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