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Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

2018-03-28Journal article Open access
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dc.contributor.authorZoran, Tamara
dc.contributor.authorSartori, Bettina
dc.contributor.authorSappl, Laura
dc.contributor.authorAigner, Maria
dc.contributor.authorSánchez-Reus, Ferran
dc.contributor.authorRezusta, Antonio
dc.contributor.authorChowdhary, Anuradha
dc.contributor.authorTaj-Aldeen, Saad J.
dc.contributor.authorArendrup, Maiken C.
dc.contributor.authorOliveri, Salvatore
dc.contributor.authorKontoyiannis, Dimitrios P.
dc.contributor.authorAlastruey-Izquierdo, Ana
dc.contributor.authorLagrou, Katrien
dc.contributor.authorCascio, Giuliana Lo
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorBuzina, Walter
dc.contributor.authorFarina, Claudio
dc.contributor.authorDrogari-Apiranthitou, Miranda
dc.contributor.authorGrancini, Anna
dc.contributor.authorTortorano, Anna M.
dc.contributor.authorWillinger, Birgit
dc.contributor.authorHamprecht, Axel
dc.contributor.authorJohnson, Elizabeth
dc.contributor.authorKlingspor, Lena
dc.contributor.authorArsic-Arsenijevic, Valentina
dc.contributor.authorCornely, Oliver A.
dc.contributor.authorMeletiadis, Joseph
dc.contributor.authorPrammer, Wolfgang
dc.contributor.authorTullio, Vivian
dc.contributor.authorVehreschild, Jörg-Janne
dc.contributor.authorTrovato, Laura
dc.contributor.authorLewis, Russell E.
dc.contributor.authorSegal, Esther
dc.contributor.authorRath, Peter-Michael
dc.contributor.authorHamal, Petr
dc.contributor.authorRodriguez-Iglesias, Manuel
dc.contributor.authorRoilides, Emmanuel
dc.contributor.authorArikan-Akdagli, Sevtap
dc.contributor.authorChakrabarti, Arunaloke
dc.contributor.authorColombo, Arnaldo L.
dc.contributor.authorFernández, Mariana S.
dc.contributor.authorMartin-Gomez, M. Teresa
dc.contributor.authorBadali, Hamid
dc.contributor.authorPetrikkos, Georgios
dc.contributor.authorKlimko, Nikolai
dc.contributor.authorHeimann, Sebastian M.
dc.contributor.authorUzun, Omrum
dc.contributor.authorRoudbary, Maryam
dc.contributor.authorde la Fuente, Sonia
dc.contributor.authorHoubraken, Jos
dc.contributor.authorRisslegger, Brigitte
dc.contributor.authorLass-Flörl, Cornelia
dc.contributor.authorLackner, Michaela
dc.date.accessioned2019-03-26T15:38:18Z
dc.date.available2019-03-26T15:38:18Z
dc.date.issued2018-03-28
dc.descriptionRaquel Sabino was not included as an author in the published article. It was corrected a posteriori.pt_PT
dc.descriptionErratum in - Corrigendum: Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon? [Front Microbiol. 2018] Front Microbiol. 2019 Jan 14;9:3245. doi: 10.3389/fmicb.2018.03245. eCollection 2018.Disponível em: https://www.frontiersin.org/articles/10.3389/fmicb.2018.03245/fullpt_PT
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882871/ | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340063/pt_PT
dc.description.abstractObjectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resistant strains remains to be studied. Methods: A global set (n = 498) of A. terreus and phenotypically related isolates was molecularly identified (beta-tubulin), tested for antifungal susceptibility against posaconazole, voriconazole, and itraconazole, and resistant phenotypes were correlated with point mutations in the cyp51A gene. Results: The majority of isolates was identified as A. terreus (86.8%), followed by A. citrinoterreus (8.4%), A. hortai (2.6%), A. alabamensis (1.6%), A. neoafricanus (0.2%), and A. floccosus (0.2%). One isolate failed to match a known Aspergillus sp., but was found most closely related to A. alabamensis. According to EUCAST clinical breakpoints azole resistance was detected in 5.4% of all tested isolates, 6.2% of A. terreus sensu stricto (s.s.) were posaconazole-resistant. Posaconazole resistance differed geographically and ranged from 0% in the Czech Republic, Greece, and Turkey to 13.7% in Germany. In contrast, azole resistance among cryptic species was rare 2 out of 66 isolates and was observed only in one A. citrinoterreus and one A. alabamensis isolate. The most affected amino acid position of the Cyp51A gene correlating with the posaconazole resistant phenotype was M217, which was found in the variation M217T and M217V. Conclusions:Aspergillus terreus was most prevalent, followed by A. citrinoterreus. Posaconazole was the most potent drug against A. terreus, but 5.4% of A. terreus sensu stricto showed resistance against this azole. In Austria, Germany, and the United Kingdom posaconazole-resistance in all A. terreus isolates was higher than 10%, resistance against voriconazole was rare and absent for itraconazole.pt_PT
dc.description.sponsorshipThis work was supported by ECMM, ISHAM, and EFISG and in part by an unrestricted research grant through the Investigator Initiated Studies Programof Astellas, MSD, and Pfizer. This study was fundet by the Christian Doppler Laboratory for invasive fungal infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Microbiol. 2018 Mar 28;9:516. doi: 10.3389/fmicb.2018.00516. eCollection 2018pt_PT
dc.identifier.doi10.3389/fmicb.2018.00516pt_PT
dc.identifier.issn1664-302X)
dc.identifier.urihttp://hdl.handle.net/10400.18/6309
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmicb.2018.00516/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAspergillus Section Terreipt_PT
dc.subjectCyp51A Alterationspt_PT
dc.subjectAzolespt_PT
dc.subjectCryptic Speciespt_PT
dc.subjectSusceptibility Profilespt_PT
dc.subjectInfeções Sistémicas e Zoonosespt_PT
dc.titleAzole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage516pt_PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume9pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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