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Exercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertension

2022-11-15Journal article Restricted access
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dc.contributor.authorMorais, Filipe
dc.contributor.authorNogueira-Ferreira, Rita
dc.contributor.authorRocha, Hugo
dc.contributor.authorDuarte, José A.
dc.contributor.authorVilarinho, Laura
dc.contributor.authorSilva, Ana F.
dc.contributor.authorLeite-Moreira, Adelino
dc.contributor.authorSantos, Mário
dc.contributor.authorFerreira, Rita
dc.contributor.authorMoreira-Gonçalves, Daniel
dc.date.accessioned2023-03-20T10:45:59Z
dc.date.available2023-03-20T10:45:59Z
dc.date.issued2022-11-15
dc.description.abstractExercise training provides several cardiovascular benefits in both physiological and pathological conditions; however, its use as a therapeutic tool for pulmonary arterial hypertension (PAH) has been poorly explored. This study aimed to extend the comprehension of the cardioprotective effects of exercise training in the set of PAH focusing on the metabolic changes promoted by exercise in the right ventricle (RV). The monocrotaline animal model of PAH was used and male Wistar rats were submitted to two weeks of treadmill exercise training (5 days/week, 60 min/day, 25 m/min) following disease establishment. Trained rats showed an improved diastolic function (lower end-diastolic pressure and tau) despite the presence of cardiac overload (increased peak systolic pressure, end-diastolic pressure and arterial elastance). This enhanced hemodynamic response was paralleled by an increased uptake of glucose to cardiomyocytes through glucose transporter type 4 (GLUT4) followed by increased lactate dehydrogenase (LDH) activity. Exercise did not reverse the decrease of fatty acid oxidation related to PAH but increased the content of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and peroxisome proliferator-activated receptor gamma (PPAR-γ). Two weeks of exercise did not modulate the changes in amino acid metabolism secondary to PAH. Our work suggests that continuous aerobic exercise of moderate intensity, despite its short-term duration and application in a late stage of the disease, supports the RV response to PAH by promoting a shift in the cardiac metabolic phenotype.pt_PT
dc.description.abstractHighlights: Two weeks of exercise training improved right ventricle diastolic function in MCT rats; Exercise increased glucose uptake through GLUT4 and its oxidation to lactate; Exercise did not reverse MCT-induced decrease reliance of RV on fatty acid oxidation; Exercise moderately impacted amino acid metabolism in the RV of MCT rats; Metabolic adaptations of trained RV are regulated by PGC-1α and PPAR-γ.pt_PT
dc.description.sponsorshipThis work was supported by “Fundação para a Ciência e a Tecnologia” – FCT, European Union, QREN, FEDER and COMPETE for funding the LAQV-REQUIMTE (UIDB/50006/2020), UnIC (UIDB/IC/00051/2020 and UIDP/00051/2020), CIAFEL (UIDB/00617/2020) and UMIB (UIDB/00215/2020 and UIDP/00215/2020) research units, RISE - Health Research Network-From the Lab to the Community (LA/P/0053/ 2020), ITR - Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020) and the research projects DOCnet (NORTE-01-0145-FEDER-000003) and NETDIAMOND (SAICT-PAC/ 0047/2015). Rita Nogueira-Ferreira acknowledges FCT for the research contract CEECIND/03935/2021 under the CEEC Individual 2021.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Biochem Biophys. 2022 Nov 15;730:109419. doi: 10.1016/j.abb.2022.109419. Epub 2022 Sep 29.pt_PT
dc.identifier.doi10.1016/j.abb.2022.109419pt_PT
dc.identifier.issn0003-9861
dc.identifier.urihttp://hdl.handle.net/10400.18/8562
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCardiovascular Research and Development Center
dc.relationCardiovascular Research and Development Center
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0003986122003046?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAcylcarnitine Profilept_PT
dc.subjectGlucose Metabolismpt_PT
dc.subjectPulmonary Arterial Hypertensionpt_PT
dc.subjectRight Ventriclept_PT
dc.subjectTreadmill Exercisept_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleExercise training counteracts the cardiac metabolic remodelling induced by experimental pulmonary arterial hypertensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCardiovascular Research and Development Center
oaire.awardTitleCardiovascular Research and Development Center
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00051%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00051%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00215%2F2020/PT
oaire.citation.startPage109419pt_PT
oaire.citation.titleArchives of Biochemistry and Biophysicspt_PT
oaire.citation.volume730pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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