Logo do repositório
 
Publicação

Imbalance of steroid hormones in hamsters infected with Schistosoma mansoni

2019-05-29Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorOliveira, K.C.
dc.contributor.authorCardoso, R.
dc.contributor.authorSantos, A.C.D.
dc.contributor.authorFernandes, R.
dc.contributor.authorBotelho, M.C.
dc.date.accessioned2020-04-25T11:28:43Z
dc.date.available2020-04-25T11:28:43Z
dc.date.issued2019-05-29
dc.description.abstractObjective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.pt_PT
dc.description.sponsorshipThis work was supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo – Grant 2012/50115-6) and FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER- 007274), and by UID/BIM/04293/2013.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEndocr Metab Immune Disord Drug Targets. 2019;19(8):1122-1126. doi: 10.2174/1871530319666190529121204.pt_PT
dc.identifier.doi10.2174/1871530319666190529121204pt_PT
dc.identifier.issn1871-5303
dc.identifier.urihttp://hdl.handle.net/10400.18/6520
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relation.publisherversionhttp://www.eurekaselect.com/172321/articlept_PT
dc.subjectSchistosoma mansoni Infectionpt_PT
dc.subjectEstradiolpt_PT
dc.subjectHost-parasite Interactionpt_PT
dc.subjectInfertilitypt_PT
dc.subjectProgesteronept_PT
dc.subjectSteroid Hormonespt_PT
dc.subjectTestosteronept_PT
dc.subjectEstradiolpt_PT
dc.subjectInfertilitypt_PT
dc.subjectTestosteronept_PT
dc.subjectProgesteronept_PT
dc.titleImbalance of steroid hormones in hamsters infected with Schistosoma mansonipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT
oaire.citation.endPage1126pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1122pt_PT
oaire.citation.titleEndocrine, Metabolic and Immune Disorders - Drug Targetspt_PT
oaire.citation.volume19pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfa9009ed-65e1-4108-bd20-1304211124ea
relation.isProjectOfPublication.latestForDiscoveryfa9009ed-65e1-4108-bd20-1304211124ea

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma.pdf
Tamanho:
435.79 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DPSPDNT - Artigos em revistas internacionais