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Methadone, Pierre Robin sequence and other congenital anomalies: case-control study

2020-03Journal article Restricted access
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dc.contributor.authorCleary, Brian
dc.contributor.authorLoane, Maria
dc.contributor.authorAddor, Marie-Claude
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorde Walle, Hermien E.K.
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorGatt, Miriam
dc.contributor.authorKlungsoyr, Kari
dc.contributor.authorMcDonnell, Bob
dc.contributor.authorNeville, Amanda
dc.contributor.authorPierini, Anna
dc.contributor.authorRissmann, Anke
dc.contributor.authorTucker, David F.
dc.contributor.authorZurriaga, Oscar
dc.contributor.authorDolk, Helen
dc.date.accessioned2022-02-03T15:35:04Z
dc.date.available2022-02-03T15:35:04Z
dc.date.issued2020-03
dc.descriptionCarlos Matias Dias - Centro de Estudos e Registo de Anomalias Congénitas, Instituto Nacional de Saúde Doutor Ricardo Jorgept_PT
dc.description.abstractObjective: Methadone is a vital treatment for women with opioid use disorder in pregnancy. Previous reports suggested an association between methadone exposure and Pierre Robin sequence (PRS), a rare craniofacial anomaly. We assessed the association between gestational methadone exposure and PRS. Design/setting: This case-malformed control study used European Surveillance of Congenital Anomalies population-based registries in Ireland, the Netherlands, Italy, Switzerland, Croatia, Malta, Portugal, Germany, Wales, Norway and Spain, 1995-2011. Patients: Cases included PRS based on International Classification of Disease (ICD), Ninth Edition-British Paediatric Association (BPA) code 75 603 or ICD, Tenth Edition-BPA code Q8708. Malformed controls were all non-PRS anomalies, excluding genetic conditions, among live births, fetal deaths from 20 weeks' gestation and terminations of pregnancy for fetal anomalies. An exploratory analysis assessed the association between methadone exposure and other congenital anomalies (CAs) excluding PRS. Methadone exposure was ascertained from medical records and maternal interview. Results: Among 87 979 CA registrations, there were 127 methadone-exposed pregnancies and 336 PRS cases. There was an association between methadone exposure and PRS (OR adjusted for registry 12.3, 95% CI 5.7 to 26.8). In absolute terms, this association reflects a risk increase from approximately 1-12 cases per 10 000 births. A raised OR was found for cleft palate (adjusted OR 5.0, 95% CI 2.7 to 9.2). Conclusions: These findings suggest that gestational methadone exposure is associated with PRS. The association may be explained by unmeasured confounding factors. The small increased risk of PRS in itself does not alter the risk-benefit balance for gestational methadone use. The association with cleft palate, a more common CA, should be assessed with independent data.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Dis Child Fetal Neonatal Ed . 2020 Mar;105(2):151-157. doi: 10.1136/archdischild-2019-316804. Epub 2019 Jun 22.pt_PT
dc.identifier.doi10.1136/archdischild-2019-316804pt_PT
dc.identifier.issn1359-2998
dc.identifier.urihttp://hdl.handle.net/10400.18/7918
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Group/ Royal College of Paediatrics and Child Healthpt_PT
dc.relation.publisherversionhttps://fn.bmj.com/content/105/2/151.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectPierre Robin Sequencept_PT
dc.subjectCleft Palatept_PT
dc.subjectMethadonept_PT
dc.subjectOpioid Use Disorderpt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectObservação em Saúde e Vigilânciapt_PT
dc.subjectRENACpt_PT
dc.subjectRegisto Nacional de Anomalias Congénitaspt_PT
dc.titleMethadone, Pierre Robin sequence and other congenital anomalies: case-control studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage157pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage151pt_PT
oaire.citation.titleArchives of Disease in Childhood. Fetal and Neonatal Editionpt_PT
oaire.citation.volume105pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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