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Paralytic shellfish poisoning due to ingestion of contaminated mussels: a 2018 case report in Caparica (Portugal)

2019-09-25Journal article Restricted access
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dc.contributor.authorLopes de Carvalho, I.
dc.contributor.authorPelerito, A.
dc.contributor.authorRibeiro, I.
dc.contributor.authorCordeiro, R.
dc.contributor.authorNúncio, M.S.
dc.contributor.authorVale, P.
dc.date.accessioned2020-04-28T22:01:18Z
dc.date.available2020-04-28T22:01:18Z
dc.date.issued2019-09-25
dc.description.abstractIn Portugal, the potent paralytic shellfish toxins (PSTs) have appeared irregularly since the onset of a national monitoring program for marine biotoxins in 1986. In years where high contamination levels were attained in bivalves, sporadic cases of human poisonings have been recorded, as in 1994 and 2007. The reappearance of high contamination levels led to the appearance of new cases during the autumn of 2018. This study details toxin ingestion, symptomatology and toxin elimination and metabolization in the fluids of two patients, who ingested mussels from the Portuguese southwest coast and required hospitalization due to the severity of symptoms. Toxin elimination was confirmed by ELISA in plasma and urine samples. In mussel samples, the toxin profile obtained by HPLC-FLD displayed a wide diversity of toxins, typical of Gymnodinum catenatum ingestion. However, in the urine samples, the toxin profile was reduced to B1 and dcSTX. Abundant compounds in mussels having an O- sulphate at C11, such as C1þ2 and dcGTX2þ3, were absent in urine. In plasma, PSTs were not detected by HPLC- FLD. Calculated toxin ingestion, resulting from consumption of an estimated 200-g portion, was in the range of 104–120 μg STX eq./kg b. w.pt_PT
dc.description.abstractHighlights: Since 1986 Gymnodinium catenatum contaminates irregularly bivalves in Portugal with PSTs; Acute neurological symptomology, such as paraesthesias, has often required hospitalization; During an episode in October 2018, toxins in fluids of two victims and toxin ingestion were studied; Preliminary confirmation was done by ELISA in serum and urine; PSP toxins with an O-sulphate at C11, abundant in mussels, were absent in urine.pt_PT
dc.description.sponsorshipFunding was obtained from INSA and from IPMA’s ‘SNMB-MONITOR’ (FEAMP–2020) projects. A grant to IR from ‘SNMB-MONITOR’ (FEAMP–2020) is acknowledged.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxicon: X. 2019;4:100017. doi: 10.1016/j.toxcx.2019.100017pt_PT
dc.identifier.doi10.1016/j.toxcx.2019.100017pt_PT
dc.identifier.issn2590-1710
dc.identifier.urihttp://hdl.handle.net/10400.18/6546
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2590171019300141pt_PT
dc.subjectParalytic Shellfish Poisoningpt_PT
dc.subjectSaxitoxinpt_PT
dc.subjectSeafood Poisoningpt_PT
dc.subjectHuman samplespt_PT
dc.subjectHPLCpt_PT
dc.subjectELISApt_PT
dc.subjectPortugalpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleParalytic shellfish poisoning due to ingestion of contaminated mussels: a 2018 case report in Caparica (Portugal)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage100017pt_PT
oaire.citation.titleToxicon: Xpt_PT
oaire.citation.volume4pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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