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Primary and oxidative DNA damage induced by titanium dioxide nanoparticles in salivary leukocytes: a non-invasive alternative in nanomaterials genotoxicity assessment

2021-04-03Conference object Restricted access
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dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorRodríguez-Fernández, R.
dc.contributor.authorLema-Arranz, C.
dc.contributor.authorPásaro, E.
dc.contributor.authorReis, Ana Teresa
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Carla
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2022-07-09T18:11:27Z
dc.date.available2022-07-09T18:11:27Z
dc.date.issued2021-04-03
dc.description.abstractIntroduction Metal oxide nanoparticles (NP) have a wide variety of applications in consumer products and biomedical practices. Recently, salivary leucocytes have been proposed as non-invasive alternative to peripheral blood leucocytes to evaluate the toxic effects of recent exposure to environmental contaminants, particularly those involving inhalatory or oral exposure routes. The present study aimed at evaluating the potential genotoxicity of titanium dioxide (TiO2) NP, frequently present in consumer products, in salivary leucocytes in vitro. Primary and oxidative DNA damage were evaluated by the standard alkaline comet assay and the hOGG1 enzyme incubation modification, respectively. Possible interferences of the NP with the methodological procedure or the OGG1 activity were addressed prior to analyses.pt_PT
dc.description.sponsorshipXunta de Galicia [ED431B 2019/02], Ministerio de Educación, Cultura y Deporte [BEAGAL18/00142 V.V.], Deputación Provincial de A Coruña [N.F.-B.], CA17140 NANO2CLINIC COST Action, FEDER through COMPETE2020-POCI/FCT [POCI-01-0145-FEDER-029651; SFRH/BPD/122112/2016].
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8159
dc.language.isoengpt_PT
dc.subjectDNA Damagept_PT
dc.subjectTitanium Dioxidept_PT
dc.subjectNanoparticlespt_PT
dc.subjectNanomaterialspt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectComet Assaypt_PT
dc.subjectSalivary Leucocytes
dc.subjectGenotoxicidade Ambiental
dc.titlePrimary and oxidative DNA damage induced by titanium dioxide nanoparticles in salivary leukocytes: a non-invasive alternative in nanomaterials genotoxicity assessmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title10th International Conference on Nanotoxicology (NANOTOX), 20-22 april 2021pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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