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HBM4EU chromates study: untargeted metabolomics study of workers exposed to hexavalent chromium

2023-06-21Conference object Restricted access
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dc.contributor.authorKozłowska, Lucyna
dc.contributor.authorSantonen, T.
dc.contributor.authorDuca, R.C.
dc.contributor.authorGodderis, L.
dc.contributor.authorJagiello, K.
dc.contributor.authorJanasik, B.
dc.contributor.authorVan Nieuwenhuyse, A.
dc.contributor.authorPoels, K.
dc.contributor.authorPuzyn, T.
dc.contributor.authorScheepers, P.
dc.contributor.authorSijko, M.
dc.contributor.authorSilva, Maria João
dc.contributor.authorSosnowska, A.
dc.contributor.authorViegas, S.
dc.contributor.authorVerdonck, J.
dc.contributor.authorWąsowicz, W.
dc.contributor.authorHBM4EU Chromates Study Team and Statistical Team
dc.date.accessioned2024-02-06T10:37:42Z
dc.date.available2024-02-06T10:37:42Z
dc.date.issued2023-06-21
dc.description.abstractDue to the wide use of Cr(VI), a large number of workers in a variety of industries are ex-posed to the potential harmful effects of this compound. The aim of this study was to inves-tigate changes in metabolic pathways in response to Cr(VI) exposure and to search for new urinary biomarkers. The study included 220 male workers who were exposed to Cr(VI) (through welding, chromium plating, surface treatment) and 102 male controls from Bel-gium, Finland, Poland, Portugal, and the Netherlands. Urinary metabolite profiles were de-termined using liquid chromatography mass spectrometry. The changes in the abundancy of excreted metabolites observed in post-shift workers vs. controls reflect fatty acid and mon-oamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes mainly in steroid hormones. We observed that: argininosuccinic acid, ubiquinone-1, indole-3-propionicacid, 6-hydroxyphenylpropionylglycine, 20-oxo-leukotriene E4, 3,4-dihydroxybenzylamine, 3,4-dimethoxyphenylethylamine and succinylacetone are potential biomarkers for Cr(VI) exposure (area under the curve > 0.9). The results of our study could form the basis for vali-dating early biomarkers of Cr(VI) exposure and their application in screening tests, and also serve as a starting point for further targeted metabolomics studies to better understand the disorders associated with Cr(VI) exposure.pt_PT
dc.description.sponsorshipSamples for this study were collected under the HBM4EU program. Metabolomics research was supported by the National Science Centre, Poland, grant number 2019/33B/NZ7/01441.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/9040
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectEarly Bbiologic Effectspt_PT
dc.subjectOccupational Healthpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU chromates study: untargeted metabolomics study of workers exposed to hexavalent chromiumpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title12th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-12), 21-23 June 2023pt_PT
oaire.fundingStreamH2020
person.familyNameSilva
person.givenNameMaria Joao
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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