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Iodine supplementation: compliance and association with adverse obstetric and neonatal outcomes

2022-01-01Journal article Open access
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dc.contributor.authorLopes-Pereira, Maria
dc.contributor.authorQuialheiro, Anna
dc.contributor.authorCosta, Patrício
dc.contributor.authorRoque, Susana
dc.contributor.authorCorreia Santos, Nadine
dc.contributor.authorCorreia-Neves, Margarida
dc.contributor.authorGoios, Ana
dc.contributor.authorCarvalho, Ivone
dc.contributor.authorKorevaar, Tim I.M.
dc.contributor.authorVilarinho, Laura
dc.contributor.authorPalha, Joana Almeida
dc.date.accessioned2023-02-28T12:45:33Z
dc.date.available2023-02-28T12:45:33Z
dc.date.issued2022-01-01
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34981750/pt_PT
dc.description.abstractObjectives: Over 1.9 billion people worldwide are living in areas estimated to be iodine insufficient. Strategies for iodine supplementation include campaigns targeting vulnerable groups, such as women in pre-conception, pregnancy and lactation. Portuguese women of childbearing age and pregnant women were shown to be mildly-to-moderately iodine deficient. As a response, in 2013, the National Health Authority (NHA) issued a recommendation that all women considering pregnancy, pregnant or breastfeeding, take a daily supplement of 150-200 μg iodine. This study explored how the iodine supplementation recommendation has been fulfilled among pregnant and lactating women in Portugal, and whether the reported iodine supplements intake impacted on adverse obstetric and neonatal outcomes. Design and methods: Observational retrospective study on pregnant women who delivered or had a fetal loss in the Braga Hospital and had their pregnancies followed in Family Health Units. Results: The use of iodine supplements increased from 25% before the recommendation to 81% after the recommendation. This was mostly due to an increase in the use of supplements containing iodine only. Iodine supplementation was protective for the number of adverse obstetric outcomes (odds ratio (OR) = 0.791, P = 0.018) and for neonatal morbidities (OR = 0.528, P = 0.024) after controlling for relevant confounding variables. Conclusion: The recommendation seems to have succeeded in implementing iodine supplementation during pregnancy. National prospective studies are now needed to evaluate the impact of iodine supplementation on maternal thyroid homeostasis and offspring psychomotor development and on whether the time of the beginning of iodine supplementation (how early during preconception or pregnancy) is relevant to consider.pt_PT
dc.description.sponsorshipThis work has been funded by National funds, through the Foundation for Science and Technology (FCT) – project UIDB/50026/2020 and UIDP/50026/2020 and by the project NORTE-01-0145-FEDER-000039, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Funding agencies did not participate in any part of the research or in data or manuscript preparationpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur Thyroid J. 2022 Jan 1;11(1):e210035. doi: 10.1530/ETJ-21-0035pt_PT
dc.identifier.doi10.1530/ETJ-21-0035pt_PT
dc.identifier.issn2235-0802
dc.identifier.urihttp://hdl.handle.net/10400.18/8536
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioScientificapt_PT
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relation.publisherversionhttps://etj.bioscientifica.com/view/journals/etj/11/1/ETJ-21-0035.xmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIodinept_PT
dc.subjectNeonatal Outcomespt_PT
dc.subjectNewbornpt_PT
dc.subjectObstetric Outcomespt_PT
dc.subjectPregnancypt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleIodine supplementation: compliance and association with adverse obstetric and neonatal outcomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLA - ICVS/3B's - Associate Laboratory
oaire.awardTitleLA - ICVS/3B's - Associate Laboratory
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.startPagee210035pt_PT
oaire.citation.titleEuropean Thyroid Journalpt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication4b09703b-1d57-4d95-9cdf-9a36a2886c9d
relation.isProjectOfPublication0e00acf0-f83c-43ca-93f7-26e48ca7ee50
relation.isProjectOfPublication.latestForDiscovery4b09703b-1d57-4d95-9cdf-9a36a2886c9d

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