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Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016

2019-08-15Journal article Open access
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dc.contributor.authorJarlier, Vincent
dc.contributor.authorDiaz Högberg, Liselotte
dc.contributor.authorHeuer, Ole E.
dc.contributor.authorCampos, José
dc.contributor.authorEckmanns, Tim
dc.contributor.authorGiske, Christian G.
dc.contributor.authorGrundmann, Hajo
dc.contributor.authorJohnson, Alan P
dc.contributor.authorKahlmeter, Gunnar
dc.contributor.authorMonen, Jos
dc.contributor.authorPantosti, Annalisa
dc.contributor.authorRossolini, Gian Maria
dc.contributor.authorvan de Sande-Bruinsma, Nienke
dc.contributor.authorVatopoulos, Alkiviadis
dc.contributor.authorŻabicka, Dorota
dc.contributor.authorŽemličková, Helena
dc.contributor.authorMonnet, Dominique L.
dc.contributor.authorSimonsen, Gunnar Skov
dc.contributor.authorEARS-Net Participants
dc.date.accessioned2020-09-15T14:10:07Z
dc.date.available2020-09-15T14:10:07Z
dc.date.issued2019-08-15
dc.descriptionEARS-Net Participants: Portugal (Manuela Caniça, National Institute of Health Doutor Ricardo Jorge)pt_PT
dc.description.abstractBackground: Antibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.AimOur objective was to compare the country-specific species distribution of the four Gram-negative species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species and the proportions of selected acquired resistance traits within these species.MethodWe used data reported for 2016 to the European Antimicrobial Resistance Surveillance Network (EARS-Net) by 30 countries in the European Union and European Economic Area.ResultsThe country-specific species distribution varied considerably. While E. coli accounted for 31.9% to 81.0% (median: 69.0%) of all reported isolates, the two most common intrinsically resistant species P. aeruginosa and Acinetobacter spp. combined (PSEACI) accounted for 5.5% to 39.2% of isolates (median: 10.1%). Similarly, large national differences were noted for the percentages of acquired non-susceptibility to third-generation cephalosporins, carbapenems and fluoroquinolones. There was a strong positive rank correlation between the country-specific percentages of PSEACI and the percentages of non-susceptibility to the above antibiotics in all four species (rho > 0.75 for 10 of the 11 pairs of variables tested).ConclusionCountries with the highest proportion of P. aeruginosa and Acinetobacter spp. were also those where the rates of acquired non-susceptibility in all four studied species were highest. The differences are probably related to national differences in antibiotic consumption and infection prevention and control routines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2019 Aug;24(33):1800538. doi: 10.2807/1560-7917.ES.2019.24.33.1800538pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2019.24.33.1800538pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/7192
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation.publisherversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.33.1800538
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGram-negative bacillipt_PT
dc.subjectAntibiotic Resistancept_PT
dc.subjectBacterial Infectionspt_PT
dc.subjectBloodstream Infectionpt_PT
dc.subjectResistência aos Antimicrobianos
dc.titleStrong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue33pt_PT
oaire.citation.startPage1800538pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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