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Interlaboratory Validation of the Cell Transformation Assay (CTA) for Carcinogenic Assessment of BPA Alternatives

2025-06-02Documento de conferência Acesso restrito
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datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorEl Yamani, N.
dc.contributor.authorAimonen, K.
dc.contributor.authorDusinska, M.
dc.contributor.authorGuichard, Y.
dc.contributor.authorHonza, T.
dc.contributor.authorLouro, H.
dc.contributor.authorPereira, M.J.
dc.contributor.authorRundén-Pran, E.
dc.contributor.authorSenGupta, T.
dc.contributor.authorTavares, A.M.
dc.contributor.authorSilva, M.J.
dc.date.accessioned2026-03-03T17:08:36Z
dc.date.available2026-03-03T17:08:36Z
dc.date.issued2025-06-02
dc.description.abstractBisphenol A (BPA) has long been used in various plastic products, resins and coatings, making human exposure to this chemical inevitable. Due to its harmful health effects, including endocrine disruption, and immunotoxicity, BPA has been increasingly replaced by several alternative compounds. However, there are still significant gaps in research regarding the safety of these BPA alternatives, particularly concerning their potential carcinogenicity. One of the in vitro assays to assess carcinogenic potential of chemicals is the Bhas-42 cell transformation assay (CTA). The assay can detect both genotoxic and non-genotoxic carcinogens It is valuable in identifying potential cancer risks before widespread exposure occurs, contributing to the development of safer chemicals and products, as well as better regulatory standards while adhering to the 3R concept. The EU-Partnership for the Assessment of Risks from Chemicals (PARC) project is addressing these research gaps to enhance the risk assessment of BPA alternatives. BPA and some alternatives, including BPZ, BPE, BPAP, BPA-MAE, BPP, and TCBPA, were selected for evaluation of their carcinogenic potential using the in vitro 2-stage Bhas-42 CTA. A key objective of the project is to validate the CTA as a reliable in vitro method for assessing carcinogenicity. To ensure consistency and accuracy across participating labs, an interlaboratory comparison was initiated and a standardized SOP was developed, including concentration ranges for controls and BPA analogues, in alignment with OECD guidance document. The first results from the protocol harmonization, using the selected controls, were consistent across all participating labs. BPA and its analogues are being tested, and the results are under evaluation. The data generated will contribute to the overall weight of evidence on the hazards posed by these chemicals and, when combined with findings from other endpoints, will provide a solid basis for refining their regulation.eng
dc.identifier.urihttp://hdl.handle.net/10400.18/11058
dc.language.isoeng
dc.peerreviewedn/a
dc.relationEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarcinogenic Potential
dc.subjectBisphenol A (BPA)
dc.subjectHealth Effects
dc.subjectAlternatives
dc.subjectGenotoxicidade Ambiental
dc.titleInterlaboratory Validation of the Cell Transformation Assay (CTA) for Carcinogenic Assessment of BPA Alternativeseng
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumber10044992
oaire.awardTitleEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
oaire.awardURIhttp://hdl.handle.net/10400.18/10383
oaire.citation.conferenceDate2025-06-02
oaire.citation.conferencePlaceBratislava, Slovakia
oaire.citation.title53rd European Environment Mutagenesis and Genomics Society meeting (EEMGS), 2-5 June 2025
oaire.fundingStreamHorizon Europe Guarantee
oaire.versionhttp://purl.org/coar/version/c_b1a7d7d4d402bcce
relation.isProjectOfPublicationa7df9a6a-838e-406c-94c7-1baa7daba05c
relation.isProjectOfPublication.latestForDiscoverya7df9a6a-838e-406c-94c7-1baa7daba05c

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