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Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017

2018-08-16Journal article Open access
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dc.contributor.authorNdumbi, P.
dc.contributor.authorFreidl, G.S.
dc.contributor.authorWilliams, C.J.
dc.contributor.authorMårdh, O.
dc.contributor.authorVarela, C.
dc.contributor.authorAvellón, A.
dc.contributor.authorFriesema, I.
dc.contributor.authorVennema, H.
dc.contributor.authorBeebeejaun, K.
dc.contributor.authorNgui, S.L.
dc.contributor.authorEdelstein, M.
dc.contributor.authorSmith-Palmer, A.
dc.contributor.authorMurphy, N.
dc.contributor.authorDean, J.
dc.contributor.authorFaber, M.
dc.contributor.authorWenzel, J.
dc.contributor.authorKontio, M.
dc.contributor.authorMüller, L.
dc.contributor.authorMidgley, S.E.
dc.contributor.authorSundqvist, L.
dc.contributor.authorEderth, J.L.
dc.contributor.authorRoque-Afonso, A.M.
dc.contributor.authorCouturier, E.
dc.contributor.authorKlamer, S.
dc.contributor.authorRebolledo, J.
dc.contributor.authorSuin, V.
dc.contributor.authorAberle, S.W.
dc.contributor.authorSchmid, D.
dc.contributor.authorDe Sousa, R.
dc.contributor.authorAugusto, G.F.
dc.contributor.authorAlfonsi, V.
dc.contributor.authorDel Manso, M.
dc.contributor.authorCiccaglione, A.R.
dc.contributor.authorMellou, K.
dc.contributor.authorHadjichristodoulou, C.
dc.contributor.authorDonachie, A.
dc.contributor.authorBorg, M.L.
dc.contributor.authorSočan, M.
dc.contributor.authorPoljak, M.
dc.contributor.authorSeveri, E.
dc.contributor.authorMembers Of The European Hepatitis A Outbreak Investigation Team
dc.date.accessioned2019-02-15T15:44:05Z
dc.date.available2019-02-15T15:44:05Z
dc.date.issued2018-08-16
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205254/pt_PT
dc.description.abstractBetween 1 June 2016 and 31 May 2017, 17 European Union (EU) and European Economic Area countries reported 4,096 cases associated with a multi-country hepatitis A (HA) outbreak. Molecular analysis identified three co-circulating hepatitis A virus (HAV) strains of genotype IA: VRD_521_2016, V16-25801 and RIVM-HAV16-090. We categorised cases as confirmed, probable or possible, according to the EU outbreak case definitions. Confirmed cases were infected with one of the three outbreak strains. We investigated case characteristics and strain-specific risk factors for transmission. A total of 1,400 (34%) cases were confirmed; VRD_521_2016 and RIVM-HAV16-090 accounted for 92% of these. Among confirmed cases with available epidemiological data, 92% (361/393) were unvaccinated, 43% (83/195) travelled to Spain during the incubation period and 84% (565/676) identified as men who have sex with men (MSM). Results depict an HA outbreak of multiple HAV strains, within a cross-European population, that was particularly driven by transmission between non-immune MSM engaging in high-risk sexual behaviour. The most effective preventive measure to curb this outbreak is HAV vaccination of MSM, supplemented by primary prevention campaigns that target the MSM population and promote protective sexual behaviour.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2018 Aug;23(33):pii=1700641. doi: 10.2807/1560-7917.ES.2018.23.33.1700641pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2018.23.33.1700641pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/5835
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEurosurveillancept_PT
dc.relation.publisherversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2018.23.33.1700641pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHepatitis Apt_PT
dc.subjectHepatitis A Viruspt_PT
dc.subjectMen Who Have Sex With Men - MSMpt_PT
dc.subjectSexually TRransmitted Infectionspt_PT
dc.subjectVaccine-preventable Diseasespt_PT
dc.subjectVaccines and Immunisationpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleHepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1700641pt_PT
oaire.citation.issue33pt_PT
oaire.citation.startPagepii=1700641pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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