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Methicillin-Resistant Staphylococcus aureus: The Shifting Landscape in the United Arab Emirates

2025-01-02Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
dc.contributor.authorBoucherabine, Syrine
dc.contributor.authorNassar, Rania
dc.contributor.authorMohamed, Lobna
dc.contributor.authorHabous, Maya
dc.contributor.authorNabi, Anju
dc.contributor.authorHusain, Riyaz Amirali
dc.contributor.authorAlfaresi, Mubarak
dc.contributor.authorOommen, Seema
dc.contributor.authorKhansaheb, Hamda Hassan
dc.contributor.authorAl Sharhan, Mouza
dc.contributor.authorCeliloglu, Handan
dc.contributor.authorRaja, Mubarak Hussain
dc.contributor.authorAbdelkarim, Eman
dc.contributor.authorAli, Nishi
dc.contributor.authorTausif, Salman
dc.contributor.authorOlowoyeye, Victory
dc.contributor.authorSoares, Nelson Cruz
dc.contributor.authorHachim, Mahmood
dc.contributor.authorMoradigaravand, Danesh
dc.contributor.authorEverett, Dean
dc.contributor.authorMueller, Elke
dc.contributor.authorMonecke, Stefan
dc.contributor.authorEhricht, Ralf
dc.contributor.authorSenok, Abiola
dc.date.accessioned2026-01-20T14:42:36Z
dc.date.available2026-01-20T14:42:36Z
dc.date.issued2025-01-02
dc.descriptionThis article belongs to the Special Issue The Molecular Epidemiology and Antimicrobial Resistance of MRSA.
dc.description.abstractBackground: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA's genetic evolution and epidemiology in the country. Methods: To investigate this influence, genomic profiling of 310 MRSA clinical isolates collected between February and November 2022 was performed using a DNA microarray-based assay. Results: Isolates were assigned to 22 clonal complexes and 72 distinct strain assignments. The predominant clonal complexes were CC5, CC6, CC361, CC22, CC1, and CC8. Community-acquired MRSA lineages were dominant, with only one healthcare-associated MRSA lineage isolate identified. Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton-Valentine leukocidin (pvl) genes and missing tst1 or enterotoxin genes. The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (tst1+/PVL+), was identified. Pvl genes were observed in 36% of the isolates, primarily from skin and soft tissue infections, while fusC (SCC-borne fusidic acid resistance) was identified in 13% of the isolates. Conclusions: The findings highlight the ongoing evolution of MRSA in the UAE, with the persistence and emergence of diverse and rare clonal complexes, driving the need for continuous genomic surveillance.eng
dc.description.sponsorshipThis research was funded by an internal research grant from Mohammed Bin Rashid University of Medicine and Health Sciences, UAE (Ref#: MBRU-CM-RG2022-01). This study was supported by the Al Jalila Foundation.
dc.identifier.citationAntibiotics (Basel). 2025 Jan 2;14(1):24. doi: 10.3390/antibiotics14010024
dc.identifier.doi10.3390/antibiotics14010024
dc.identifier.eissn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.18/10725
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/2079-6382/14/1/24
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMRSA
dc.subjectStaphylococcus Aureus
dc.subjectAntimicrobial Resistance
dc.subjectGenotyping
dc.subjectMicroarray
dc.subjectGenómica Funcional e Estrutural
dc.titleMethicillin-Resistant Staphylococcus aureus: The Shifting Landscape in the United Arab Emirateseng
dc.typejournal article
dcterms.referenceshttps://www.mdpi.com/article/10.3390/antibiotics14010024/s1
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage24
oaire.citation.titleAntibiotics
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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