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Publicação
Overview of proteomics studies in obstructive sleep apnea
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Orientador(es)
Resumo(s)
Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious
effects on metabolic and cardiovascular health. Although much has been learned regarding the
pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated
with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies
have become a fundamental approach for identifying novel disease mediators as potential diagnostic
and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology
and the technological advances in proteomics and the first results of its application to address critical
issues in the OSA field.
Descrição
Palavras-chave
Sleep Apneia Obstructive Sleep Apnea Biomarkers Proteomics Mass Spectrometry Lung Metabolic Disorders Genomica Funcional Genómica Funcional e Estrutural
Contexto Educativo
Citação
Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14
Editora
Elsevier/ World Association of Sleep Medicine and International Pediatric Sleep Association