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Contribution to nanomaterials safety assessment: the need of integrating in vitro, in vivo and in silico strategies

2015-03-11Conference object Restricted access
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dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorBorges, Teresa
dc.contributor.authorLavinha, João
dc.contributor.authorAlbuquerque, José Maria
dc.date.accessioned2016-02-18T13:22:39Z
dc.date.available2016-02-18T13:22:39Z
dc.date.issued2015-03-11
dc.description.abstractFundamental and application-driven research in nanotechnology is expected to boost nanoscience and innovation towards development of safe-by-design nanomaterials(NM). In this scenario, adding vast societal benefits, a multi-disciplinary approach to responsible innovation must be undertaken. Although the widespread use of NM, it is not clear whether they impact on environment and human health, on the long-term. Potential deleterious effects, e.g., genotoxicity that is intimately associated with carcinogenicity, have to be assessed using complementary in vitro and in vivo assays, nested within the conventional risk assessment paradigm and considering specific physicochemical properties of NM. In this study we present the testing strategy that was recently applied to the genotoxicity characterization of titanium dioxide nanomaterials in human cells and in an integrative in vivo model. The results supported the view that a thorough understanding of the relationship between the physicochemical properties, the behaviour of NM in biological systems and their mechanism of action is of utmost importance to predict their biological activity. In conclusion, the knowledge gap between nanoscience and hazard assessment has to be filled within a multi-disciplinary approach including experimental and computational components in an iterative process, towards an improved strategy for the safety evaluation of nanomaterials.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/3397
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.subjectToxicologia Genéticapt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectNanotoxicologiapt_PT
dc.subjectNanomaterialspt_PT
dc.subjectAvaliação do Risco
dc.subjectNanotoxicology
dc.subjectNanomaterials
dc.titleContribution to nanomaterials safety assessment: the need of integrating in vitro, in vivo and in silico strategiespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceVeneza, Itáliapt_PT
oaire.citation.titleSustainable Nanotechnology Conference 2015, 9-11 março 2015pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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