Rare variants targeting genes that encode cytochrome P450 enzymes in Autism Spectrum Disorder

Xavier Santos, João; Marques, Ana Rita; Martiniano, Hugo; Vilela, Joana; Rasga, Célia; Oliveira, Guiomar; Moura Vicente, Astrid

http://hdl.handle.net/10400.18/6666

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Autores

Moura Vicente, Astrid

Resumo(s)

Autism Spectrum Disorder (ASD) heritability estimates of 50-80% support the hypothesis that gene-environment interactions play a role in this pathology. ASD risk has been associated with early exposure to various xenobiotics that are cleared in the liver by Cytochrome P450 enzymes. We therefore explored the hypothesis that variants in CYP450 genes, which define the rapid or slow metabolizer status of their carriers, may render individuals exposed to certain toxicants more susceptible to brain disruption during early development.

Palavras-chave

Autism Spectrum Disorder Perturbações do Desenvolvimento Infantil e Saúde Mental Autismo

URI

http://hdl.handle.net/10400.18/6666

Coleções

DPSPDNT - Posters/abstracts em congressos internacionais

Licença CC

cclicense-by-nc

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