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Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries

2022-12-01Journal article Open access
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dc.contributor.authorMorris, Joan K.
dc.contributor.authorWellesley, Diana
dc.contributor.authorLimb, Elizabeth
dc.contributor.authorBergman, Jorieke E.H.
dc.contributor.authorKinsner‐Ovaskainen, Agnieszka
dc.contributor.authorAddor, Marie Claude
dc.contributor.authorBroughan, Jennifer M.
dc.contributor.authorCavero‐Carbonell, Clara
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorEchevarría‐González‐de‐Garibay, Luis‐Javier
dc.contributor.authorGatt, Miriam
dc.contributor.authorHaeusler, Martin
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorKlungsoyr, Kari
dc.contributor.authorLelong, Nathalie
dc.contributor.authorMaterna‐Kiryluk, Anna
dc.contributor.authorNeville, Amanda
dc.contributor.authorNelen, Vera
dc.contributor.authorO'Mahony, Mary T.
dc.contributor.authorPerthus, Isabelle
dc.contributor.authorPierini, Anna
dc.contributor.authorRankin, Judith
dc.contributor.authorRissmann, Anke
dc.contributor.authorRouget, Florence
dc.contributor.authorSayers, Geraldine
dc.contributor.authorStevens, Sarah
dc.contributor.authorTucker, David
dc.contributor.authorGarne, Ester
dc.date.accessioned2023-01-09T15:16:51Z
dc.date.available2023-01-09T15:16:51Z
dc.date.issued2022-12-01
dc.description[Corrections added after online publication, 16 November 2022: The last name of Dr. Jennifer M. Broughan was incorrectly spelled in the initial publication. It has been corrected.]pt_PT
dc.description.abstractBackground: Younger mothers are at a greater risk of having a pregnancy with gastroschisis and the risk is higher in the United Kingdom than other European countries. Gastroschisis is thought to be a vascular disruption anomaly and the aim of this study was to analyze the prevalence of other possible vascular disruption anomalies to determine whether both the younger maternal age and the UK associations also occur with these anomalies. Methods: All pregnancies with anomalies considered potentially due to vascular disruption from January 1, 2005 to December 31, 2017 from 26 European population-based congenital anomaly registries who were members of EUROCAT were analyzed. Multilevel models were used to allow for differences between registries when analyzing associations with maternal age, year of birth and whether the registry was in the United Kingdom. Results: There were 5,220 cases with potential vascular disruption anomalies, excluding chromosomal and genetic conditions, with a prevalence of 8.85 per 10,000 births in the United Kingdom and 5.44 in the other European countries. The prevalence per 10,000 births of gastroschisis (4.45 vs. 1.56) and congenital constriction bands (0.83 vs. 0.42) was significantly higher in the United Kingdom, even after adjusting for maternal age. However, transverse limb reduction defects had a similar prevalence (2.16 vs. 2.14 per 10,000). The expected increased prevalence in younger mothers was observed for vascular disruption anomalies overall and for the individual anomalies: gastroschisis and congenital constriction bands. Conclusion: Vascular disruption anomalies that had an increased risk for younger mothers (such as gastroschisis) had a higher maternal age standardized prevalence in the United Kingdom, while vascular disruption anomalies with weaker associations with younger mothers (such as transverse limb reduction defects) did not have an increased prevalence in the United Kingdom, which may indicate a different etiology for these anomalies.pt_PT
dc.description.sponsorshipEuropean Commissionpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBirth Defects Res . 2022 Dec 1;114(20):1417-1426. doi: 10.1002/bdr2.2122. Epub 2022 Nov 11.pt_PT
dc.identifier.doi10.1002/bdr2.2122pt_PT
dc.identifier.issn2472-1727
dc.identifier.urihttp://hdl.handle.net/10400.18/8409
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/bdr2.2122pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCongenital Anomaliespt_PT
dc.subjectVascular Disruptionpt_PT
dc.subjectMaternal Agept_PT
dc.subjectEUROCATpt_PT
dc.subjectEuropean Surveillance of Congenital Anomaliespt_PT
dc.subjectEuropept_PT
dc.subjectRENACpt_PT
dc.subjectRegisto Nacional de Anomalias Congénitaspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectObservação em Saúde e Vigilânciapt_PT
dc.subjectPortugalpt_PT
dc.titlePrevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1426pt_PT
oaire.citation.issue20pt_PT
oaire.citation.startPage1417pt_PT
oaire.citation.titleBirth Defects Researchpt_PT
oaire.citation.volume114pt_PT
person.familyNameMatias Dias
person.givenNameCarlos
person.identifier.ciencia-id6311-6117-ADEB
person.identifier.orcid0000-0002-0206-5874
person.identifier.ridI-6335-2012
person.identifier.scopus-author-id23103292400
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfe9524e7-fc22-42f6-8eca-ab6a513ddd6b
relation.isAuthorOfPublication.latestForDiscoveryfe9524e7-fc22-42f6-8eca-ab6a513ddd6b

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