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New “Omics” Approaches as Tools to Explore Mechanistic Nanotoxicology

2022Book part Restricted access
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dc.contributor.authorVentura, Célia
dc.contributor.authorTorres, Vukosava
dc.contributor.authorVieira, Luís
dc.contributor.authorGomes, Bruno
dc.contributor.authorRodrigues, António Sebastião
dc.contributor.authorRueff, José
dc.contributor.authorPenque, Deborah
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-11-29T11:38:10Z
dc.date.available2022-11-29T11:38:10Z
dc.date.issued2022
dc.description.abstractIn the last years, “omics” approaches have been applied to study the toxicity of nanomaterials (NM) with the aim of obtaining insightful information on their biological effects. One of the most developed “omics” field, transcriptomics, expects to find unique profiles of differentially expressed genes after exposure to NM that, besides providing evidence of their mechanistic mode of action, may also be used as biomarkers for biomonitoring purposes. Moreover, several NM have been associated with epigenetic alterations, i.e., changes in the regulation of gene expression caused by differential DNA methylation, histone tail modification and microRNA expression. Epigenomics research focusing on DNA methylation is increasingly common and the role of microRNAs is being better understood, either promoting or suppressing biological pathways. Moreover, the proteome is a highly dynamic system that changes constantly in response to a stimulus. Therefore, proteomics can identify changes in protein abundance and/ or variability that lead to a better understanding of the underlying mechanisms of action of NM while discovering biomarkers. As to genomics, it is still not well developed in nanotoxicology. Nevertheless, the individual susceptibility to NM mediated by constitutive or acquired genomic variants represents an important component in understanding the variations in the biological response to NM exposure and, consequently, a key factor to evaluate possible adverse effects in exposed individuals. By elucidating the molecular changes that are involved NM toxicity, the new “omics” studies are expected to contribute to exclude or reduce the handling of hazardous NM in the workplace and support the implementation of regulation to protect human health.pt_PT
dc.description.sponsorshipThis work was funded by FCT/ MCTES, project PTDC/SAU-PUB/32587/2017 and project PTDC/BTM-TEC/28554/2017 through national funds (PIDDAC), ToxOmics (UIDB/00009/2020; UIDP/00009/2020) and BioISI—Biosystems & Integrative Sciences Institute, Faculty of Sciences University of Lisbon, Lisbon, Portugal. It is also a result of the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by FCT, and the National Mass Spectrometry Network (RNEM)-FCT Infrastructure Program, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIn: Louro H, Silva MJ (eds). Nanotoxicology in Safety Assessment of Nanomaterials. Springer, Cham., 2022, pp. 179-94. (Advances in Experimental Medicine and Biology;1357). https://doi.org/10.1007/978-3-030-88071-2_14pt_PT
dc.identifier.doi10.1007/978-3-030-88071-2_8pt_PT
dc.identifier.eissn2214-8019
dc.identifier.issn0065-2598
dc.identifier.urihttp://hdl.handle.net/10400.18/8366
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007/978-3-030-88071-2_8pt_PT
dc.subjectToxicogenomicspt_PT
dc.subjectEpigenomicspt_PT
dc.subjectTranscriptomicspt_PT
dc.subjectProteomicspt_PT
dc.subjectmiRNAspt_PT
dc.subjectNanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleNew “Omics” Approaches as Tools to Explore Mechanistic Nanotoxicologypt_PT
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-TEC%2F28554%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.endPage194pt_PT
oaire.citation.startPage179pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
oaire.citation.volume(Advances in Experimental Medicine and Biology;1357)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
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