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Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries

2022-07-29Journal article Open access
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dc.contributor.authorTavares, Ana Maria
dc.contributor.authorViegas, Susana
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorGöen, Thomas
dc.contributor.authorSantonen, Tiina
dc.contributor.authorLuijten, Mirjam
dc.contributor.authorKortenkamp, Andreas
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-12-09T15:12:58Z
dc.date.available2022-12-09T15:12:58Z
dc.date.issued2022-07-29
dc.descriptionThis article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future.
dc.description.abstractHexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health risk is still understudied. This study, conducted within the European Human Biomonitoring Initiative (HBM4EU), aimed at performing a mixtures risk assessment (MRA) based on published human biomonitoring (HBM) data from Cr(VI), Ni and/or PAHs occupational co-exposure in Europe. After data extraction, Risk Quotient (RQ) and Sum of Risk Quotients (SRQ) were calculated for binary and ternary mixtures to characterise the risk. Most selected articles measured urinary levels of Cr and Ni and a SRQ > 1 was obtained for co-exposure levels in welding activities, showing that there is concern regarding co-exposure to these substances. Similarly, co-exposure to mixtures of Cr(VI), Ni and PAHs in waste incineration settings resulted in SRQ > 1. In some studies, a low risk was estimated based on the single substances’ exposure level (RQ < 1), but the mixture was considered of concern (SRQ > 1), highlighting the relevance of considering exposure to the mixture rather than to its single components. Overall, this study points out the need of using a MRA based on HBM data as a more realistic approach to assess and manage the risk at the workplace, in order to protect workers’ health.pt_PT
dc.description.sponsorshipThis research was funded by European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4EU and co-funded by UIDP/00009/2020; UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Jul 29;10(8):431. doi: 10.3390/toxics10080431pt_PT
dc.identifier.doi10.3390/toxics10080431pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8389
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/431pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoring (HBM)pt_PT
dc.subjectEuropean Human Biomonitoring Initiative (HBM4EU)pt_PT
dc.subjectCo-exposurept_PT
dc.subjectWorkplacept_PT
dc.subjectMixture Risk Assessment (MRA)pt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOccupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage431pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication8836ec79-2300-487a-97ad-75e98cfabcfa
relation.isProjectOfPublicationa438b9d1-8a6a-4c90-a13b-7ccf34071451
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