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Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects

2015-07-31Journal article Restricted access
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dc.contributor.authorCalzolari, M.
dc.contributor.authorZé-Zé, Líbia
dc.contributor.authorVásquez, A.
dc.contributor.authorSeco, M.P.S.
dc.contributor.authorAmaro, Fátima
dc.contributor.authorDottori, M.
dc.date.accessioned2016-02-18T15:24:14Z
dc.date.available2018-01-01T01:30:10Z
dc.date.issued2015-07-31
dc.description.abstractSeveral flaviviruses are important pathogens for humans and animals (Dengue viruses, Japanese encephalitis virus, Yellow-fever virus, Tick-borne encephalitis virus, West Nile virus). In recent years, numerous novel and related flaviviruses without known pathogenic capacity have been isolated worldwide in the natural mosquito population. However, phylogenetic studies have shown that genomic sequences of these viruses diverge from other flaviviruses. Moreover, these viruses seem to be exclusive of insects (they do not seem to grow on vertebrate cell lines), and were already defined as mosquito-only flaviviruses or insect-specific flaviviruses. At least eleven of these viruses were isolated worldwide, and sequences ascribable to other eleven putative viruses were detected in several mosquito species. A large part of the cycle of these viruses is not well known, and their persistence in the environment is poorly understood. These viruses are detected in a wide variety of distinct mosquito species and also in sandflies and chironomids worldwide; a single virus, or the genetic material ascribable to a virus, was detected in several mosquito species in different countries, often in different continents. Furthermore, some of these viruses are carried by invasive mosquitoes, and do not seem to have a depressive action on their fitness. The global distribution and the continuous detection of new viruses in this group point out the likely underestimation of their number, and raise interesting issues about their possible interactions with the pathogenic flaviviruses, and their influence on the bionomics of arthropod hosts. Some enigmatic features, as their integration in the mosquito genome, the recognition of their genetic material in DNA forms in field-collected mosquitoes, or the detection of the same virus in both mosquitoes and sandflies, indicate that the cycle of these viruses has unknown characteristics that could be of use to reach a deeper understanding of the cycle of related pathogenic flaviviruses.pt_PT
dc.description.sponsorshipIn Italy mosquito collections were performed in the frame of the Regional project on insect borne diseases (COMM07001). In Portugal part of the mosquito collections were performed in a collaboration program with the Algarve Regional Health Administration and the research work was funded by the PTDC/SAU-SAP/119199/2010 FCT project and partially supported and by centre grant (to BioISI, Centre Reference: UID/MULTI/04046/2013) from FCT/MCTES/PIDDAC, Portugal.pt_PT
dc.identifier.citationInfect Genet Evol. 2016 Jun;40:381-8. doi: 10.1016/j.meegid.2015.07.032. Epub 2015 Jul 31.pt_PT
dc.identifier.doi10.1016/j.meegid.2015.07.032pt_PT
dc.identifier.issn1567-1348
dc.identifier.urihttp://hdl.handle.net/10400.18/3410
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1567134815003196pt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.subjectInsect-specific Flaviviruspt_PT
dc.subjectMosquito-only Flaviviruspt_PT
dc.subjectMosquitopt_PT
dc.subjectSandflypt_PT
dc.subjectCell Fusing Agent Viruspt_PT
dc.subjectKamiti River Viruspt_PT
dc.subjectCulex Flaviviruspt_PT
dc.subjectAedes Flaviviruspt_PT
dc.subjectQuang Binh Viruspt_PT
dc.subjectOchlerotatus Caspius Flaviviruspt_PT
dc.titleInsect-specific flaviviruses, a worldwide widespread group of viruses only detected in insectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-SAP%2F119199%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInfection, Genetics and Evolutionpt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicatione6f2b885-9577-481f-92d8-d5830e08d022
relation.isProjectOfPublicationdc84f768-e6f2-4eea-b294-6c8ebbd1a156
relation.isProjectOfPublication.latestForDiscoverydc84f768-e6f2-4eea-b294-6c8ebbd1a156

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