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HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium

2022-04-18Journal article Open access
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dc.contributor.authorKozłowska, Lucyna
dc.contributor.authorSantonen, Tiina
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorJagiello, Karolina
dc.contributor.authorJanasik, Beata
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorPoels, Katrien
dc.contributor.authorPuzyn, Tomasz
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorSijko, Monika
dc.contributor.authorSilva, Maria João
dc.contributor.authorSosnowska, Anita
dc.contributor.authorViegas, Susana
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorWąsowicz, Wojciech
dc.contributor.authorHBM4EU Chromates Study Team
dc.contributor.authorStatistical Team
dc.date.accessioned2022-12-05T12:39:50Z
dc.date.available2022-12-05T12:39:50Z
dc.date.issued2022-04-18
dc.descriptionThe HBM4EU Chromates study team consists of: Kukka Aimonen1, Rob Anzion2, Radia Bousoumah3, Maurice van Dael2, Karen S. Galea4, Ivo Iavicoli5, Kate Jones6, Henriqueta Louro2, Sophie Ndaw7, Simo P. Porras1, Edna Riberio8, and Riitta Velin1 Statistical team consist of: Natalia Buławska9, Dominika Jurkiewicz9 Correspondent affiliations: 1 Finnish Institute of Occupational Health, 00250 Helsinki, Finland; 2 Human Genetics Department, National Institute of Health Dr. Ricardo Jorge (INSA), Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, 1649-016 Lisbon, Portugal; 3 Comprehensive Health Research Center (CHRC), 1169-056, Lisbon, Portugal; 4 Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK; 5 Department of Public Health, University of Naples Federico II, 80131 Naples, Italy; 6 Health and Safety Executive (HSE), Harpur Hill, Buxton SK17 9JN, UK; 7 French National Research and Safety Institute, 54500, Vandoeuvre-les-Nancy, France; 8 Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisbon, 1600-560 Lisbon, Portugal; 9 QSAR Lab Ltd., 80172 Gdansk, Poland.pt_PT
dc.descriptionThis article belongs to the Special Issue Toxicometabolomics.pt_PT
dc.description.abstractExposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI).pt_PT
dc.description.sponsorshipSamples for this study were collected under the HBM4EU program. Metabolomics research was supported by the National Science Centre, Poland, grant number 2019/33B/NZ7/01441.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMetabolites. 2022 Apr 18;12(4):362. doi: 10.3390/metabo12040362pt_PT
dc.identifier.doi10.3390/metabo12040362pt_PT
dc.identifier.issn2218-1989
dc.identifier.urihttp://hdl.handle.net/10400.18/8378
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2218-1989/12/4/362pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectBiomarkerspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectMetabolic Pathwayspt_PT
dc.subjectEarly Biologic Effectspt_PT
dc.subjectOccupational Healthpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue4pt_PT
oaire.citation.startPage362pt_PT
oaire.citation.titleMetabolitespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamH2020
person.familyNameSilva
person.givenNameMaria Joao
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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