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Portuguese calculated panel reactive antibodies online estimator

2019-06Journal article Restricted access
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dc.contributor.authorLima, Bruno A.
dc.contributor.authorAlves, Helena
dc.date.accessioned2020-04-29T05:14:05Z
dc.date.available2020-04-29T05:14:05Z
dc.date.issued2019-06
dc.description.abstractCalculated panel reactive antibodies (CPRA) is a sensitization measure used to classify and prioritize transplant candidates in different kidney transplant allocation systems. CPRA is based on identification of HLA unacceptable on potential organ donors making a transplant candidate ineligible for transplantation. Here, we present a CPRA online estimator based on HLA allelic and haplotypic frequencies from Portuguese donors. We also compare the values we obtained from our CPRA estimator (Portuguese [PT]-CPRA) against CPRA values obtained from: Eurotransplant virtual PRA calculator (ET-CPRA); Canadian CPRA calculator (Canadian [CN]-CPRA) and Organ Procurement and Transplantation Network CPRA calculator (United States [US]-CPRA). When we analyzed correlations between CPRA values obtained from pairs of calculators, we observed that they are significantly and highly correlated. Bland-Altman plots for the comparison between PT-CPRA calculator against the other calculators, show higher differences between PT and CN than between PT and ET and PT and US. Also, the lowest value for Lin's concordance coefficient was obtained for the comparison between PT and CN calculators. CPRA values reliability depend on donors' pool from which it is calculated and it is crucial for classify correctly highly sensitized patients. A CPRA calculator must use donors' HLA frequencies similar from those who would be actual organ donors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHLA. 2019 Jun;93(6):445-450. doi: 10.1111/tan.13516. Epub 2019 Mar 5pt_PT
dc.identifier.doi10.1111/tan.13516pt_PT
dc.identifier.issn2059-2310
dc.identifier.urihttp://hdl.handle.net/10400.18/6550
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley and Sonspt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/tan.13516pt_PT
dc.subjectAnti-HLA Antibodiespt_PT
dc.subjectCalculated Panel Reactive Antibodiespt_PT
dc.subjectHighly Sensitized Patientspt_PT
dc.subjectKidney Transplantationpt_PT
dc.subjectPortugalpt_PT
dc.titlePortuguese calculated panel reactive antibodies online estimatorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage450pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage445pt_PT
oaire.citation.titleHLA: Immune Response Geneticspt_PT
oaire.citation.volume93pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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