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HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

2022-06-20Journal article Open access
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dc.contributor.authorJones, Kate
dc.contributor.authorGalea, Karen S.
dc.contributor.authorScholten, Bernice
dc.contributor.authorLoikala, Marika
dc.contributor.authorPorras, Simo P.
dc.contributor.authorBousoumah, Radia
dc.contributor.authorNdaw, Sophie
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorViegas, Susana
dc.contributor.authorGodderis, Lode
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorPoels, Katrien
dc.contributor.authorGӧen, Thomas
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorSantonen, Tiina
dc.contributor.authorHBM4EU Diisocyanates Study Team
dc.date.accessioned2022-12-02T15:16:24Z
dc.date.available2022-12-02T15:16:24Z
dc.date.issued2022-06-20
dc.descriptionThis article belongs to the Section Occupational Safety and Health.pt_PT
dc.description.abstractDiisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assessoccupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl–MDI–lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells(micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygienemeasurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations.pt_PT
dc.description.sponsorshipThis work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2022 Jul 20;19(14):8811. doi: 10.3390/ijerph19148811pt_PT
dc.identifier.doi10.3390/ijerph19148811pt_PT
dc.identifier.issn1661-7827
dc.identifier.urihttp://hdl.handle.net/10400.18/8371
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/19/14/8811pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectDiisocyanatespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectExposure Assessmentpt_PT
dc.subjectWorkerspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue14pt_PT
oaire.citation.startPage8811pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume19pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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