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Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis

2020-07-30Journal article Open access
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dc.contributor.authorMarcos-Pérez, Diego
dc.contributor.authorSánchez-Flores, María
dc.contributor.authorProietti, Stefania
dc.contributor.authorBonassi, Stefano
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira, Joao Paulo
dc.contributor.authorFernández-Tajes, Juan
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2022-05-18T15:48:02Z
dc.date.available2022-05-18T15:48:02Z
dc.date.issued2020-07-30
dc.description.abstractSerum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.pt_PT
dc.description.sponsorshipThis research was funded by Xunta de Galicia [ED431B 2019/02]; Ministerio de Educación, Cultura y Deporte [BEAGAL18/00142 to V.V, PRX19/00353 to B.L.]; and Deputación Provincial de A Coruña [to D.M.-P. and M.S.-F.]pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients . 2020 Jul 30;12(8):2286. doi: 10.3390/nu12082286pt_PT
dc.identifier.doi10.3390/nu12082286pt_PT
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.18/8018
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/12/8/2286pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectMeta-analysispt_PT
dc.subjectOlder Adultspt_PT
dc.subjectSystematic Reviewpt_PT
dc.subjectVitamin Dpt_PT
dc.titleLow Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage2286pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume12pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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