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Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus

2019-07-11Artigo científico Acesso restrito
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dc.contributor.authorEnkirch, T.
dc.contributor.authorSeveri, E.
dc.contributor.authorVennema, H.
dc.contributor.authorThornton, L.
dc.contributor.authorDean, J.
dc.contributor.authorBorg, M.L.
dc.contributor.authorCiccaglione, A.R.
dc.contributor.authorBruni, R.
dc.contributor.authorChristova, I.
dc.contributor.authorNgui, S.L.
dc.contributor.authorBalogun, K.
dc.contributor.authorNěmeček, V,
dc.contributor.authorKontio, M
dc.contributor.authorTakács, M
dc.contributor.authorHettmann, A
dc.contributor.authorKorotinska, R
dc.contributor.authorLöve, A
dc.contributor.authorAvellón, A
dc.contributor.authorMuñoz-Chimeno, M
dc.contributor.authorde Sousa, R
dc.contributor.authorJanta, D
dc.contributor.authorEpštein, J
dc.contributor.authorKlamer, S
dc.contributor.authorSuin, V
dc.contributor.authorAberle, SW
dc.contributor.authorHolzmann, H
dc.contributor.authorMellou, K
dc.contributor.authorEderth, JL
dc.contributor.authorSundqvist, L
dc.contributor.authorRoque-Afonso, AM
dc.contributor.authorFilipović, SK,
dc.contributor.authorPoljak, M
dc.contributor.authorVold, L
dc.contributor.authorStene-Johansen, K
dc.contributor.authorMidgley, S
dc.contributor.authorFischer, TK
dc.contributor.authorFaber, M
dc.contributor.authorWenzel, JJ
dc.contributor.authorTakkinen, J
dc.contributor.authorLeitmeyer, K
dc.date.accessioned2020-04-27T07:05:10Z
dc.date.available2020-04-27T07:05:10Z
dc.date.issued2019-07-11
dc.description.abstractSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive. Aim: The objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses. Methods: In 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases’ samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert 2 www.eurosurveillance.org consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods. Results: Of 31 EU/ EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths. Conclusions: While HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2019 Jul;24(28):1800397. doi: 10.2807/1560-7917.ES.2019.24.28.1800397pt_PT
dc.identifier.doi10.2807/1560-7917pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/6524
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation.publisherversionhttps://doi.org/10.2807/1560-7917.pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHepatitis Apt_PT
dc.subjectImproving Preparednesspt_PT
dc.subjectCross-borderpt_PT
dc.subjectEuropean Unionpt_PT
dc.subjectFoodborne Diseasespt_PT
dc.subjectHAVpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleImproving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A viruspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1800397pt_PT
oaire.citation.issue28pt_PT
oaire.citation.startPage1800397pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume24pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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