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PM10 exposure interacts with abdominal obesity to increase blood triglycerides: a cross-sectional linkage study

2021-11-11Journal article Restricted access
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dc.contributor.authorGaio, Vânia
dc.contributor.authorRoquette, Rita
dc.contributor.authorMonteiro, Alexandra
dc.contributor.authorFerreira, Joana
dc.contributor.authorLopes, Diogo
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorNunes, Baltazar
dc.date.accessioned2021-12-23T16:36:34Z
dc.date.available2023-12-31T01:30:48Z
dc.date.issued2021-11-11
dc.description.abstractBackground: Blood lipids and glucose levels dysregulation represent potential mechanisms intermediating the adverse cardiovascular effects of ambient particulate matter (PM) exposure. This study aims to estimate the effect of long-term PM10 exposure on blood lipids and glucose levels and to assess the potential mediation and/or modification action of abdominal obesity (AO) (waist-to-height ratio). Methods: Our study was based on 2,390 participants of the first Portuguese Health Examination Survey (INSEF, 2015) with available data on blood lipids and glucose parameters and living within a 30-km radius of an air quality monitoring station with available PM10 measurements. PM10 concentrations were acquired from the air quality monitoring network of the Portuguese Environment Agency. Generalized linear models were used to assess the effect of 1-year PM10 exposure on blood lipids and glucose levels. An interaction term was introduced in the models to test the modification action of AO. Results: We found an association between PM10 and non-fasting blood triglycerides (TG) after adjustment for age, sex, education, occupation, lifestyles-related variables and temperature but only in participants with AO. Per each 1 mg/m3 PM10 increment, there was a 1.84% (95% confidence interval: 0.02–3.69) increase in TG. For the remaining blood lipid and glucose parameters, no associations were found. Conclusions: Our study demonstrates that even at low levels of exposure, long-term PM10 exposure interacts with AO to increase blood TG. Our findings suggest that reducing both AO prevalence and PM10 below current standards would result in additional health benefits for the population.pt_PT
dc.description.sponsorshipINSEF was developed as part of the Pre-defined project financed under the Public Health Initiatives Programme ‘Improvement of epidemiological health information to support public health decision and management in Portugal. Towards reduced inequalities, improved health and bilateral cooperation’ with a 1.500.000e Grant from Iceland, Liechtenstein and Norway from EEA Grants and the Portuguese Government. The present study was also funded by the Portuguese Foundation for Science and Technology (FCT) (PhD Scholarship Reference: SFRH/BD/129426/2017). J.F. was funded by national funds (OE), through FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the DecreeLaw 57/2016, of August 29, changed by Law 57/2017, of July 19. CESAM received financial support by FCT/MCTES (UIDP/50017/2020 + UIDB/50017/2020), through national funds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Public Health. 2022 Apr 1;32(2):281-288. doi: 10.1093/eurpub/ckab190. Epub 2021 Nov 11.pt_PT
dc.identifier.doi10.1093/eurpub/ckab190pt_PT
dc.identifier.eissn1464-360X
dc.identifier.issn1101-1262
dc.identifier.urihttp://hdl.handle.net/10400.18/7834
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/ European Public Health Associationpt_PT
dc.relationEffects of air pollution exposure on cardiovascular outcomes: Linkage between the first National Health Examination Survey and the Environmental data
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://academic.oup.com/eurpub/advance-article-abstract/doi/10.1093/eurpub/ckab190/6425628?redirectedFrom=fulltextpt_PT
dc.subjectAbdominal Obesitypt_PT
dc.subjectBlood Triglyceridespt_PT
dc.subjectAmbient Particulate Matterpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectSaúde Públicapt_PT
dc.titlePM10 exposure interacts with abdominal obesity to increase blood triglycerides: a cross-sectional linkage studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEffects of air pollution exposure on cardiovascular outcomes: Linkage between the first National Health Examination Survey and the Environmental data
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F129426%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.startPageckab190pt_PT
oaire.citation.titleEuropean Journal of Public Healthpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5a8a3983-3f80-43a8-9729-25fbfa3ae156
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
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relation.isProjectOfPublication.latestForDiscovery0e72e6c8-b610-43e0-931c-8ad275ad6093

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