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Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability

2019-05-29Journal article Restricted access
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dc.contributor.authorFagundes, Gabriela E.
dc.contributor.authorMacan, Tamires P.
dc.contributor.authorRohr, Paula
dc.contributor.authorDamiani, Adriani P.
dc.contributor.authorRodrigues da Rocha, Franciani
dc.contributor.authorPereira, Maiara
dc.contributor.authorLongaretti, Luiza M.
dc.contributor.authorVilela, Thais C.
dc.contributor.authorCeretta, Luciane B.
dc.contributor.authorMendes, Carolini
dc.contributor.authorSilveira, Paulo C.L.
dc.contributor.authorTeixeira, João Paulo F.
dc.contributor.authorMoraes de Andrade, Vanessa
dc.date.accessioned2020-05-02T15:28:57Z
dc.date.available2020-05-02T15:28:57Z
dc.date.issued2019-05-29
dc.descriptionErratum in - Corrigendum: Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability. Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM. Mutagenesis. 2019 May 29;34(2):215. doi: 10.1093/mutage/gez006.pt_PT
dc.description.abstractType 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes. We evaluated 75 patients with type 2 diabetes, registered in the Integrated Clinics of the University of Southern Santa Catarina. Participants received 4000 IU of vitamin D3 (25(OH)D) supplementation daily for 8 weeks. Blood samples were collected at the beginning and at the end of the supplementation, and 4 weeks after the end of supplementation. The glycidic and lipid profiles [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides], oxidative stress, DNA damage and 25(OH)D levels were evaluated. Vitamin D3 supplementation for 8 weeks showed enough to significantly increase blood levels of 25(OH)D. A significant difference in lipid profile was observed only in non-HDL cholesterol. Significant changes were observed in glucose homeostasis (fasting glucose and serum insulin) and, in addition, a reduction in the parameters of oxidative stress and DNA damage. There was a significant reduction in the values of 25(OH)D 4 weeks after the end of the supplementation, but levels still remained above baseline. Use of vitamin D supplementation can be an ally in the health modulation of patients with type 2 diabetes mellituspt_PT
dc.description.sponsorshipThis work was supported by grants from Conselho Nacional de Pesquisa e Desenvolvimento (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) and Programa de Pós-Graduação em Ciências da Saúde/ Universidade do Extremo Sul Catarinense.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMutagenesis. 2019 May 29;34(2):135-145. doi: 10.1093/mutage/gez001pt_PT
dc.identifier.doi10.1093/mutage/gez001pt_PT
dc.identifier.issn0267-8357
dc.identifier.urihttp://hdl.handle.net/10400.18/6574
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/ United Kingdom Environmental Mutagen Societypt_PT
dc.relation.publisherversionhttps://academic.oup.com/mutage/article-abstract/34/2/135/5307876?redirectedFrom=fulltextpt_PT
dc.subjectDiabetes Mellituspt_PT
dc.subjectType 2 Diabetes Mellituspt_PT
dc.subjectVitamin D3pt_PT
dc.titleVitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage145pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage135pt_PT
oaire.citation.titleMutagenesispt_PT
oaire.citation.volume34pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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