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The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century

2019-09-12Journal article Open access
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dc.contributor.authorCaini, Saverio
dc.contributor.authorKusznierz, Gabriela
dc.contributor.authorGarate, Verònica Vera
dc.contributor.authorWangchuk, Sonam
dc.contributor.authorThapa, Binay
dc.contributor.authorde Paula Júnior, Francisco José
dc.contributor.authorFerreira de Almeida, Walquiria Aparecida
dc.contributor.authorNjouom, Richard
dc.contributor.authorFasce, Rodrigo A.
dc.contributor.authorBustos, Patricia
dc.contributor.authorFeng, Luzhao
dc.contributor.authorPeng, Zhibin
dc.contributor.authorAraya, Jenny Lara
dc.contributor.authorBruno, Alfredo
dc.contributor.authorde Mora, Doménica
dc.contributor.authorBarahona de Gámez, Mónica Jeannette
dc.contributor.authorPebody, Richard
dc.contributor.authorZambon, Maria
dc.contributor.authorHigueros, Rocio
dc.contributor.authorRivera, Rudevelinda
dc.contributor.authorKosasih, Herman
dc.contributor.authorCastrucci, Maria Rita
dc.contributor.authorBella, Antonino
dc.contributor.authorKadjo, Hervé A.
dc.contributor.authorDaouda, Coulibaly
dc.contributor.authorMakusheva, Ainash
dc.contributor.authorBessonova, Olga
dc.contributor.authorChaves, Sandra S.
dc.contributor.authorEmukule, Gideon O.
dc.contributor.authorHeraud, Jean-Michel
dc.contributor.authorRazanajatovo, Norosoa H.
dc.contributor.authorBarakat, Amal
dc.contributor.authorEl Falaki, Fatima
dc.contributor.authorMeijer, Adam
dc.contributor.authorDonker, Gé A.
dc.contributor.authorHuang, Q. Sue
dc.contributor.authorWood, Tim
dc.contributor.authorBalmaseda, Angel
dc.contributor.authorPalekar, Rakhee
dc.contributor.authorArévalo, Brechla Moreno
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorLee, Vernon Jian Ming
dc.contributor.authorAng, Li Wei
dc.contributor.authorCohen, Cheryl
dc.contributor.authorTreurnicht, Florette
dc.contributor.authorMironenko, Alla
dc.contributor.authorHolubka, Olha
dc.contributor.authorBresee, Joseph
dc.contributor.authorBrammer, Lynnette
dc.contributor.authorLe, Mai T.Q.
dc.contributor.authorHoang, Phuong V.M.
dc.contributor.authorEl Guerche-Séblain, Clotilde
dc.contributor.authorPaget, John
dc.contributor.authorGlobal Influenza B Study team
dc.date.accessioned2020-05-08T11:45:32Z
dc.date.available2020-05-08T11:45:32Z
dc.date.issued2019-09-12
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31513690/pt_PT
dc.description.abstractWe describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study. We included over 1.8 million influenza cases occurred in thirty-one countries during 2000-2018. We calculated the proportion of cases caused by influenza B and its lineages; determined the timing of influenza A and B epidemics; compared the age distribution of B/Victoria and B/Yamagata cases; and evaluated the frequency of lineage-level mismatch for the trivalent vaccine. The median proportion of influenza cases caused by influenza B virus was 23.4%, with a tendency (borderline statistical significance, p = 0.060) to be higher in tropical vs. temperate countries. Influenza B was the dominant virus type in about one every seven seasons. In temperate countries, influenza B epidemics occurred on average three weeks later than influenza A epidemics; no consistent pattern emerged in the tropics. The two B lineages caused a comparable proportion of influenza B cases globally, however the B/Yamagata was more frequent in temperate countries, and the B/Victoria in the tropics (p = 0.048). B/Yamagata patients were significantly older than B/Victoria patients in almost all countries. A lineage-level vaccine mismatch was observed in over 40% of seasons in temperate countries and in 30% of seasons in the tropics. The type B virus caused a substantial proportion of influenza infections globally in the 21st century, and its two virus lineages differed in terms of age and geographical distribution of patients. These findings will help inform health policy decisions aiming to reduce disease burden associated with seasonal influenza.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2019 Sep 12;14(9):e0222381. doi: 10.1371/journal.pone.0222381. eCollection 2019pt_PT
dc.identifier.doi10.1371/journal.pone.0222381pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/6616
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222381pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectEpidemicspt_PT
dc.subjectEpidemiological Monitoringpt_PT
dc.subjectFemalept_PT
dc.subjectHistory, 21st Centurypt_PT
dc.subjectHumanspt_PT
dc.subjectInfluenza A Virus, H1N1 Subtypept_PT
dc.subjectInfluenza A viruspt_PT
dc.subjectInfluenza B viruspt_PT
dc.subjectInfluenza Vaccinespt_PT
dc.subjectInfluenza, Humanpt_PT
dc.subjectMalept_PT
dc.subjectPopulation Surveillancept_PT
dc.subjectSeasonspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleThe epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st centurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPagee0222381pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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