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APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016

2023-11-03Artigo científico Acesso aberto
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dc.contributor.authorO’Toole, Áine
dc.contributor.authorNeher, Richard A.
dc.contributor.authorNdodo, Nnaemeka
dc.contributor.authorBorges, Vitor
dc.contributor.authorGannon, Ben
dc.contributor.authorGomes, João Paulo
dc.contributor.authorGroves, Natalie
dc.contributor.authorKing, David J.
dc.contributor.authorMaloney, Daniel
dc.contributor.authorLemey, Philippe
dc.contributor.authorLewandowski, Kuiama
dc.contributor.authorLoman, Nicholas
dc.contributor.authorMyers, Richard
dc.contributor.authorOmah, Ifeanyi F.
dc.contributor.authorSuchard, Marc A.
dc.contributor.authorWorobey, Michael
dc.contributor.authorChand, Meera
dc.contributor.authorIhekweazu, Chikwe
dc.contributor.authorUlaeto, David
dc.contributor.authorAdetifa, Ifedayo
dc.contributor.authorRambaut, Andrew
dc.date.accessioned2024-01-22T15:39:31Z
dc.date.available2024-01-22T15:39:31Z
dc.date.issued2023-11-03
dc.description.abstractHistorically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central Africa. However, in May 2022, human cases of mpox were detected spreading internationally beyond countries with known endemic reservoirs. When the first cases from 2022 were sequenced, they shared 42 nucleotide differences from the closest mpox virus (MPXV) previously sampled. Nearly all these mutations are characteristic of the action of APOBEC3 deaminases, host enzymes with antiviral function. Assuming APOBEC3 editing is characteristic of human MPXV infection, we developed a dual-process phylogenetic molecular clock that-inferring a rate of ~6 APOBEC3 mutations per year-estimates that MPXV has been circulating in humans since 2016. These observations of sustained MPXV transmission present a fundamental shift to the perceived paradigm of MPXV epidemiology as a zoonosis and highlight the need for revising public health messaging around MPXV as well as outbreak management and control.pt_PT
dc.description.abstractEditor’s summary: In March 2022, an international epidemic of human Mpox was detected, showing that it was not solely a zoonotic infection. A hallmark of the approximately 88,000 cases that have been reported were TC>TT and GA>AA mutations in Mpox viruses, which were acquired at a surprisingly high evolutionary rate for a pox virus. Knowing that these types of mutation are a sign of activity by a host antiviral enzyme called APOBEC3, O’Toole et al. investigated whether the mutations reflected human-to-human transmission rather than repeated zoonotic spillover. Bayesian evolutionary analysis showed that Mpox virus recently diversified into several lineages in humans that display elevated numbers of mutations, signaling APOBEC exposure and sustained human-to-human transmission rather than zoonosis as the source of new cases. —Caroline Ashpt_PT
dc.description.sponsorshipWellcome Trust ARTIC (Collaborators Award 206298/Z/17/Z, ARTIC network) (Á.O.T., P.L., M.A.S., A.R.); European Research Council (grant agreement no. 725422 – ReservoirDOCS) (P.L., M.A.S., A.R.); National Institutes of Health (R01 AI153044) (P.L., M.A.S., A.R.); David and Lucile Packard Foundation (M.W.); Research Foundation, Flanders– Fonds voor Wetenschappelijk Onderzoek–Vlaanderen, G066215N, G0D5117N and G0B9317N (P.L.); HORIZON 2020 EU grant 874850 MOOD (P.L.); HERA project (grant/2021/PHF/23776) supported by the European Commission through the European Centre for Disease Control and Prevention (V.B. and J.P.G.). The Nigeria Centre for Disease Control and Prevention receives core funding from the Nigerian government.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScience. 2023 Nov 3;382(6670):595-600. doi: 10.1126/science.adg8116. Epub 2023 Nov 2.pt_PT
dc.identifier.doi10.1126/science.adg8116pt_PT
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/10400.18/8947
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relationThe evolutionary dynamics of pathogen emergence and establishment: from Reservoir Detection to Outbreak Control
dc.relationMOnitoring Outbreak events for Disease surveillance in a data science context
dc.relation.publisherversionhttps://www.science.org/doi/10.1126/science.adg8116pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMpox Viruspt_PT
dc.subjectMonkeypox Viruspt_PT
dc.subjectGeneticspt_PT
dc.subjectEpidemiologypt_PT
dc.subjectTransmissionpt_PT
dc.subjectMutationpt_PT
dc.subjectPhylogenypt_PT
dc.subjectAPOBEC Deaminasespt_PT
dc.subjectHuman MPXV infectionpt_PT
dc.subjectInfecções Emergentespt_PT
dc.titleAPOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe evolutionary dynamics of pathogen emergence and establishment: from Reservoir Detection to Outbreak Control
oaire.awardTitleMOnitoring Outbreak events for Disease surveillance in a data science context
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/725422/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/874850/EU
oaire.citation.endPage600pt_PT
oaire.citation.issue6670pt_PT
oaire.citation.startPage595pt_PT
oaire.citation.titleSciencept_PT
oaire.citation.volume382pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com a página web da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication04164626-c213-47a7-8a89-5c24f81eabbe
relation.isProjectOfPublication75ce2606-25eb-4dac-8a3e-33064933fe79
relation.isProjectOfPublication.latestForDiscovery75ce2606-25eb-4dac-8a3e-33064933fe79

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