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The effect of TB patient delay on loss to follow-up in Portugal

2023-07-01Journal article Restricted access
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dc.contributor.authorMarques, J.
dc.contributor.authorRocha, J.V.
dc.contributor.authorSoares, Patricia
dc.contributor.authorLeite, Andreia
dc.contributor.authorDuarte, R.
dc.contributor.authorNunes, C.
dc.date.accessioned2023-10-10T14:18:06Z
dc.date.available2023-10-10T14:18:06Z
dc.date.issued2023-07-01
dc.description.abstractBACKGROUND: Early identification of TB cases, followed by treatment to completion, are essential for controlling and preventing the disease. Previous studies have found some factors associated with both loss to follow-up (LTFU) and patient delay. We aim to build a causal model to investigate the association between TB patient delay and LTFU.METHODS: Pulmonary TB cases were identified using the national surveillance system in Portugal between 2008 and 2017. A directed acyclic graph was used to identify the minimal set of variables to adjust for when studying the association between delay (exposure) and LTFU (outcome). Crude and adjusted hazard were estimated using Cox regression.RESULTS: Nearly 4% of the patients did not follow up treatment. There was no association between patient delay and LTFU, even after adjustment with the minimal set of covariates. Factors associated with a higher risk of LTFU were being younger, being unemployed, living in urban areas, having HIV and the abuse of alcohol and drugs.CONCLUSION: Patient delay was not associated with LTFU, while social conditions were. Future research should investigate the underlying reasons why patients discontinue TB treatment and use these findings to develop targeted interventions that can support patients in completing their treatment regimen.pt_PT
dc.description.sponsorshipThis work was supported by the Fundacão para a Ciência e a Tecnologia (FCT; Lisbon, Portugal) (Grant: PTDC/SAU-PUB/31346/2017). The present publication was funded by Fundacão Ciˆencia e Tecnologia, IP national support through CHRC (UIDP/04923/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Tuberc Lung Dis. 2023 Jul 1;27(7):537-542. doi: 10.5588/ijtld.22.0623pt_PT
dc.identifier.doi10.5588/ijtld.22.0623pt_PT
dc.identifier.issn1027-3719
dc.identifier.urihttp://hdl.handle.net/10400.18/8685
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIngentapt_PT
dc.relationFrom symptoms to diagnosis of Urban Tuberculosis, considering individual and contextual factors. What are the determinants and critical points of this delay?s pathway?
dc.relation.publisherversionhttps://www.ingentaconnect.com/content/iuatld/ijtld/2023/00000027/00000007/art00007pt_PT
dc.subjectTuberculosispt_PT
dc.subjectLost to Follow-Uppt_PT
dc.subjectDiagnosticpt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectTuberculosept_PT
dc.subjectDiagnósticopt_PT
dc.titleThe effect of TB patient delay on loss to follow-up in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFrom symptoms to diagnosis of Urban Tuberculosis, considering individual and contextual factors. What are the determinants and critical points of this delay?s pathway?
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F31346%2F2017/PT
oaire.citation.endPage542pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage537pt_PT
oaire.citation.titleThe International Journal of Tuberculosis and Lung Diseasept_PT
oaire.citation.volume27pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameSoares
person.familyNameLeite
person.givenNamePatricia
person.givenNameAndreia
person.identifier1050496
person.identifier1052436
person.identifier.ciencia-id0415-632D-8609
person.identifier.ciencia-id2F10-F9A9-E8A7
person.identifier.orcid0000-0001-5033-9115
person.identifier.orcid0000-0003-0843-0630
person.identifier.scopus-author-id52063758300
person.identifier.scopus-author-id57109931300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication838ff85b-16c9-4992-b13f-e3099f916717
relation.isAuthorOfPublication.latestForDiscoverydf1b8bab-1e35-4561-92d0-8aeb17371a29
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