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Towards a systematic use of effect biomarkers in population and occupational biomonitoring

2020-12-15Journal article Restricted access
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dc.contributor.authorZare Jeddi, Maryam
dc.contributor.authorHopf, Nancy B.
dc.contributor.authorViegas, Susana
dc.contributor.authorPrice, Anna Bal
dc.contributor.authorPaini, Alicia
dc.contributor.authorvan Thriel, Christoph
dc.contributor.authorBenfenati, Emilio
dc.contributor.authorNdaw, Sophie
dc.contributor.authorBessems, Jos
dc.contributor.authorBehnisch, Peter A.
dc.contributor.authorLeng, Gabriele
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorVerhagen, Hans
dc.contributor.authorCubadda, Francesco
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorAli, Imran
dc.contributor.authorDavid, Arthur
dc.contributor.authorMustieles, Vicente
dc.contributor.authorFernandez, Mariana F.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorPasanen-Kase, Robert
dc.date.accessioned2021-03-07T17:18:10Z
dc.date.available2021-03-07T17:18:10Z
dc.date.issued2020-12-15
dc.descriptionReviewpt_PT
dc.description.abstractEffect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations, and highlight their potential in monitoring humans exposed to chemical mixtures. We also discuss the role of the adverse outcome pathway (AOP) framework and physiologically based kinetic and dynamic (PBK/D) modelling to strengthen the understanding of the biological mechanism of effect biomarkers, and in particular for use in regulatory risk assessments. An interdisciplinary network of experts from the European chapter of the International Society for Exposure Science (ISES Europe) and the Organization for Economic Co-operation and Development (OECD) Occupational Biomonitoring activity of Working Parties of Hazard and Exposure Assessment group worked together to map the conventional framework of biomarkers and provided recommendations for their systematic use. We summarized the key aspects of this work here, and discussed these in three parts. Part I, we inventory available effect biomarkers and promising new biomarkers for the general population based on the H2020 Human Biomonitoring for Europe (HBM4EU) initiative. Part II, we provide an overview AOP and PBK/D modelling use that improved the selection and interpretation of effect biomarkers. Part III, we describe the collected expertise from the OECD Occupational Biomonitoring subtask effect biomarkers in prioritizing relevant mode of actions (MoAs) and suitable effect biomarkers. Furthermore, we propose a tiered risk assessment approach for occupational biomonitoring. Several effect biomarkers, especially for use in occupational settings, are validated. They offer a direct assessment of the overall health risks associated with exposure to chemicals, chemical mixtures and their transformation products. Promising novel effect biomarkers are emerging for biomonitoring of the general population. Efforts are being dedicated to prioritizing molecular and biochemical effect biomarkers that can provide a causal link in exposure-health outcome associations. This mechanistic approach has great potential in improving human health risk assessment. New techniques such as in silico methods (e.g. QSAR, PBK/D modelling) as well as 'omics data will aid this process. Our multidisciplinary review represents a starting point for enhancing the identification of effect biomarkers and their mechanistic pathways following the AOP framework. This may help in prioritizing the effect biomarker implementation as well as defining threshold limits for chemical mixtures in a more structured way. Several ex vivo biomarkers have been proposed to evaluate combined effects including genotoxicity and xeno-estrogenicity. There is a regulatory need to derive effect-based trigger values using the increasing mechanistic knowledge coming from the AOP framework to address adverse health effects due to exposure to chemical mixtures. Such a mechanistic strategy would reduce the fragmentation observed in different regulations. It could also stimulate a harmonized use of effect biomarkers in a more comparable way, in particular for risk assessments to chemical mixtures.pt_PT
dc.description.abstractHighlights: Reliable effect biomarkers are available for most of the relevant MoAs; Increasing AOP knowledge fosters the use of effect biomarkers in regulatory context; PBK/D models allow interpretation and simulation of biomarkers of effect; An inter-regulatory setting of effect-based trigger values is demanded; Effect-biomarkers have in many cases reached a level of maturity ensuring use in mixture assessments.pt_PT
dc.description.sponsorshipWe would like to thank Dr, Michel Hauser from Swiss SECO, for providing the health based occupational background and Thomas Goen ¨ from German DFG and HBM Commission, Dave Marsh, Exxon Mobile UK (representing CEFIC) and Devika Poddalgoda from Health Canada for their discussions and suggestions in the OECD occupational biomonitoring subtask on effect biomarker. Moreover, we would like to thank Tiina Santonen from Finnish Institute for Occupational Health (FIOH). In addition, we specifically acknowledge the work package 14 (HBM4EU WP14) for their valuable work on the effect biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Int. 2021 Jan;146:106257. doi: 10.1016/j.envint.2020.106257. Epub 2020 Dec 15.pt_PT
dc.identifier.doi10.1016/j.envint.2020.106257pt_PT
dc.identifier.issn0160-4120
dc.identifier.urihttp://hdl.handle.net/10400.18/7360
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Pergamonpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0160412020322121?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAdverse Outcome Pathways (AOP)pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectEffect Biomarkerspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectExposure Sciencept_PT
dc.subjectMixture Assessmentpt_PT
dc.subjectPhysiologically Based Pharmacokinetic (PBPK)pt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleTowards a systematic use of effect biomarkers in population and occupational biomonitoringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106257pt_PT
oaire.citation.titleEnvironment Internationalpt_PT
oaire.citation.volume146pt_PT
person.familyNameLouro
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242

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