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Association between exposure to airborne endocrine disrupting chemicals and asthma in children or adolescents: A systematic review and meta-analysis

2025-02-08Artigo científico Acesso aberto
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dc.contributor.authorHatem, Georges
dc.contributor.authorFaria, Ana Margarida
dc.contributor.authorPinto, Mariana Bessa
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorSalamova, Amina
dc.contributor.authorCosta, Carla
dc.contributor.authorMadureira, Joana
dc.date.accessioned2026-02-20T16:57:01Z
dc.date.available2026-02-20T16:57:01Z
dc.date.issued2025-02-08
dc.description.abstractVarious studies have explored the association between Endocrine Disrupting Chemicals (EDCs) exposure and children's and adolescents' respiratory health, showing potential long-term effects and links to asthma. This systematic review explores the association between exposure to seven EDC groups during school age and adolescence and asthma onset or exacerbation while highlighting the predominant compounds underlying these potential associations. PubMed, Web of Science, Scopus, and Cochrane Library databases were searched with no time restriction. The risk of bias and heterogeneity across the included studies were assessed using the Newcastle Ottawa scale and I2 test, respectively. Pooled Odds Ratios (OR) and their 95% Confidence Intervals (CI) were calculated using the random effect model, and the quality of evidence for each outcome was measured using the GRADE approach. The review included 64851 children and adolescents from 61 observational studies, most with a low risk of bias in the studied domains. The pooled OR for asthma onset was significant for phthalates in dust samples (OR:1.21, CI:1.02; 1.44). Due to limited studies, the overall pooled effects for the other groups were not computed. Individual compounds demonstrating significant associations with asthma onset included airborne nickel (OR:1.10, CI:1.03; 1.18) and zinc (OR:1.13, CI:1.11; 1.15), urinary Bisphenol S (OR:1.40, CI:1.13; 1.73), Bisphenol A (OR:1.57, CI:1.02; 2.40) and arsenic (OR:2.08, CI:1.33; 3.26), and DiBP (OR:1.41, CI:1.08; 1.82), DEHP (OR:1.89, CI:1.00; 3.57), and TBOEP (OR:2.61, CI:1.08; 6.30) in the dust. Individual compounds with significant associations with greater asthma exacerbation odds comprised airborne nickel (OR:1.08, CI:1.01; 1.16) and zinc (OR:1.09, CI:1.01; 1.17), and urinary MEHHP (OR:1.24, CI:1.02; 1.51), MECPP (OR:1.30, CI:1.07; 1.57), MEOHP (OR:1.30, CI:1.09; 1.55), and MCOP (OR:1.32, CI:1.11; 1.57). Exposure to EDCs was significantly associated with asthma onset and exacerbation in children and adolescents, namely for phthalates, bisphenols A and S, arsenic, nickel, and zinc. Further research is recommended to focus on the impact of synergistic and co-exposure to other indoor air pollutants.eng
dc.description.abstractHighlights: - Limited evidence led to pooling the effect only for phthalates among 7 EDC groups. - Higher phthalates levels in dust were associated with 1.21 higher asthma onset odds. - Higher DEHP, DiBP, TBOEP, BPA, BPS and Arsenic levels linked with asthma onset odds. - Higher MCOP, MECPP, MEHHP, MEOHP, Ni and Zn levels linked to exacerbation odds. - Insignificant associations with OH-pyrene, formaldehyde, and triclosan with asthma.eng
dc.description.sponsorshipThe authors wish to thank the Foundation for Science and Technology (FCT, Portugal) for financial support to the EDC(Mind)2 project (PTDC/CTA-AMB/3040/2021; DOI https://doi.org/10.54499/PTDC/CTA-AMB/3040/2021), the Epidemiology Research Unit–Institute of Public Health, University of Porto, Portugal (EPIUnit: UIDB/04750/2020; DOI https://doi.org/10.54499/UIDB/04750/2020), the Laboratory for Integrative and Translational Research in Population Health (ITR: LA/P/0064/2020; DOI https://doi.org/10.54499/LA/P/0064/2020), and the individual fellowship 2022.11261.BD.
dc.identifier.citationEnviron Pollut. 2025 Mar 15:369:125830. doi: 10.1016/j.envpol.2025.125830. Epub 2025 Feb 8
dc.identifier.doi10.1016/j.envpol.2025.125830
dc.identifier.issn0269-7491
dc.identifier.pmid39929430
dc.identifier.urihttp://hdl.handle.net/10400.18/10978
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.relationPTDC/CTA-AMB/3040/2021
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0269749125002039?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAsthma Exacerbation
dc.subjectChildhood Asthma
dc.subjectEndocrine Disruptors
dc.subjectEnvironmental Exposure
dc.subjectMeta-analysis
dc.subjectSystematic Review
dc.subjectAr e Saúde Ocupacional
dc.subjectAvaliação do Risco
dc.subjectToxicologia
dc.titleAssociation between exposure to airborne endocrine disrupting chemicals and asthma in children or adolescents: A systematic review and meta-analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/CTA-AMB/3040/2021
oaire.awardNumberUIDB/04750/2020
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCTA-AMB%2F3040%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.citation.startPage125830
oaire.citation.titleEnvironmental Pollution
oaire.citation.volume369
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicationd2b25b54-c60e-4030-bb5a-660fbf0426a9
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication.latestForDiscoveryd2b25b54-c60e-4030-bb5a-660fbf0426a9

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