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Temporal variations in the short-term effects of ambient air pollution on cardiovascular and respiratory mortality: a pooled analysis of 380 urban areas over a 22-year period

2024-09Journal article Open access
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dc.contributor.authorSchwarz, Maximilian
dc.contributor.authorPeters, Annette
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorde'Donato, Francesca
dc.contributor.authorSera, Francesco
dc.contributor.authorBell, Michelle L
dc.contributor.authorGuo, Yuming
dc.contributor.authorHonda, Yasushi
dc.contributor.authorHuber, Veronika
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorUrban, Aleš
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorMasselot, Pierre
dc.contributor.authorLavigne, Eric
dc.contributor.authorAchilleos, Souzana
dc.contributor.authorKyselý, Jan
dc.contributor.authorSamoli, Evangelia
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorFook Sheng Ng, Chris
dc.contributor.authorSilva, Susana
dc.contributor.authorMadureira, Joana
dc.contributor.authorGarland, Rebecca M.
dc.contributor.authorTobias, Aurelio
dc.contributor.authorArmstrong, Ben
dc.contributor.authorSchwartz, Joel
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorSchneider, Alexandra
dc.contributor.authorBreitner, Susanne
dc.contributor.authorKan, Haidong
dc.contributor.authorOsorio, Samuel
dc.contributor.authorOrru, Hans
dc.contributor.authorIndermitte, Ene
dc.contributor.authorMaasikmets, Marek
dc.contributor.authorRyti, Niilo
dc.contributor.authorPascal, Mathilde
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorAnalitis, Antonis
dc.contributor.authorEntezari, Alireza
dc.contributor.authorMayvaneh, Fatemeh
dc.contributor.authorKim, Yoonhee
dc.contributor.authorAlahmad, Barrak
dc.contributor.authorHurtado Diaz, Magali
dc.contributor.authorFélix Arellano, Eunice Elizabeth
dc.contributor.authorRao, Shilpa
dc.contributor.authorDiz-Lois Palomares, Alfonso
dc.contributor.authorScovronick, Noah
dc.contributor.authorAcquaotta, Fiorella
dc.contributor.authorKim, Ho
dc.contributor.authorLee, Whanhee
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorForsberg, Bertil
dc.contributor.authorRagettli, Martina S.
dc.contributor.authorGuo, Yue Leon
dc.contributor.authorPan, Shih-Chun
dc.contributor.authorLi, Shanshan
dc.contributor.authorZanobetti, Antonella
dc.date.accessioned2025-03-24T16:07:50Z
dc.date.available2025-03-24T16:07:50Z
dc.date.issued2024-09
dc.description.abstractBackground: Ambient air pollution, including particulate matter (such as PM10 and PM2·5) and nitrogen dioxide (NO2), has been linked to increases in mortality. Whether populations' vulnerability to these pollutants has changed over time is unclear, and studies on this topic do not include multicountry analysis. We evaluated whether changes in exposure to air pollutants were associated with changes in mortality effect estimates over time. Methods: We extracted cause-specific mortality and air pollution data collected between 1995 and 2016 from the Multi-Country Multi-City (MCC) Collaborative Research Network database. We applied a two-stage approach to analyse the short-term effects of NO2, PM10, and PM2·5 on cause-specific mortality using city-specific time series regression analyses and multilevel random-effects meta-analysis. We assessed changes over time using a longitudinal meta-regression with time as a linear fixed term and explored potential sources of heterogeneity and two-pollutant models. Findings: Over 21·6 million cardiovascular and 7·7 million respiratory deaths in 380 cities across 24 countries over the study period were included in the analysis. All three air pollutants showed decreasing concentrations over time. The pooled results suggested no significant temporal change in the effect estimates per unit exposure of PM10, PM2·5, or NO2 and mortality. However, the risk of cardiovascular mortality increased from 0·37% (95% CI -0·05 to 0·80) in 1998 to 0·85% (0·55 to 1·16) in 2012 with a 10 μg/m3 increase in PM2·5. Two-pollutant models generally showed similar results to single-pollutant models for PM fractions and indicated temporal differences for NO2. Interpretation: Although air pollution levels decreased during the study period, the effect sizes per unit increase in air pollution concentration have not changed. This observation might be due to the composition, toxicity, and sources of air pollution, as well as other factors, such as socioeconomic determinants or changes in population distribution and susceptibility.pt_PT
dc.description.abstractQuestions answered in this article: - How do the findings from different countries regarding air pollution effects on mortality vary?; - What is the significance of this multicountry, multicity study in understanding air pollution effects over time?; - What exploratory secondary analyses were conducted to investigate the effects of air pollution on mortality?; - How many cities and countries were included in the analysis of air pollution effects on mortality?; - Why is it important to understand temporal trends in air pollution effects for future health estimates?por
dc.description.sponsorshipAG was supported by the European Union's Horizon 2020 Project Exhaustion (grant number 820655). FS was supported by the Italian Ministry of University and Research, Department of Excellence project 2023–2027 ReDS “Rethinking Data Science”—Department of Statistics, Computer Science and Applications, University of Florence. AMV-C acknowledges funding from the Swiss National Science Foundation (grant number TMSGI3_211626). JJKJ was supported by the Academy of Finland (grant number 310372; Global Health Risks Related to Atmospheric Composition and Weather Consortium).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Planet Health. 2024 Sep;8(9):e657-e665. doi: 10.1016/S2542-5196(24)00168-2
dc.identifier.doi10.1016/S2542-5196(24)00168-2pt_PT
dc.identifier.issn2542-5196
dc.identifier.pmid39243781
dc.identifier.urihttp://hdl.handle.net/10400.18/10462
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relation310372
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2542519624001682?via%3Dihub
dc.relation.publisherversionhttps://www.thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00168-2/fulltextpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMortalitypt_PT
dc.subjectShort-Term Effectspt_PT
dc.subjectMCCpt_PT
dc.subjectAir Pollutionpt_PT
dc.subjectEnvironmental Exposure
dc.subjectNitrogen Dioxide
dc.subjectCardiovascular Diseases
dc.subjectRespiratory Tract Diseases
dc.subjectEurope
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectAvaliação do Risco
dc.titleTemporal variations in the short-term effects of ambient air pollution on cardiovascular and respiratory mortality: a pooled analysis of 380 urban areas over a 22-year periodpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.citation.endPagee665pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPagee657pt_PT
oaire.citation.titleThe Lancet Planetary Health
oaire.citation.volume8pt_PT
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamedas Neves Pereira da Silva
person.familyNameMadureira
person.givenNameSusana
person.givenNameJoana
person.identifierV-1284-2017
person.identifier.ciencia-idB718-8EF6-EBD8
person.identifier.ciencia-idCE16-D7E0-30D5
person.identifier.orcid0000-0003-2524-0548
person.identifier.orcid0000-0001-5279-877X
person.identifier.scopus-author-id8881942100
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication49b180bc-3e03-4347-9e32-5725fd7142f8
relation.isAuthorOfPublication59f77eac-1a04-4551-b59e-fdb0be8f28a0
relation.isAuthorOfPublication.latestForDiscovery59f77eac-1a04-4551-b59e-fdb0be8f28a0
relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
relation.isProjectOfPublication.latestForDiscovery59609b8b-2750-43e0-8fe9-155a4915a572

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