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Human biomonitoring in health risk assessment in Europe: current practices and recommendations for the future

2019-06-05Journal article Restricted access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorHeinälä, Milla
dc.contributor.authorBessems, Jos
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorVermeire, Theo
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorvan Engelen, Jacqueline
dc.contributor.authorBorges, Teresa
dc.contributor.authorRousselle, Christophe
dc.contributor.authorOugier, Eva
dc.contributor.authorAlvito, Paula
dc.contributor.authorMartins, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSilva, Maria João
dc.contributor.authorPronk, Anjoeka
dc.contributor.authorSchaddelee-Scholten, Bernice
dc.contributor.authorDel Carmen Gonzalez, Maria
dc.contributor.authorde Alba, Mercedes
dc.contributor.authorCastaño, Argelia
dc.contributor.authorViegas, Susana
dc.contributor.authorHumar-Juric, Tatjana
dc.contributor.authorKononenko, Lijana
dc.contributor.authorLampen, Alfonso
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorSchoeters, Greet
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2020-04-25T11:08:46Z
dc.date.available2020-04-25T11:08:46Z
dc.date.issued2019-06-05
dc.description.abstractHuman biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples on the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017-2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe, and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analysed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of a EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 HBM4EU, and received co-funding from the author's organizations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2019 Jun;222(5):727-737. doi: 10.1016/j.ijheh.2019.05.009. Epub 2019 Jun 5.pt_PT
dc.identifier.doi10.1016/j.ijheh.2019.05.009pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/6518
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Urban and Fischerpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463919301543?via%3Dihubpt_PT
dc.subjectChemicalspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectPublic Healthpt_PT
dc.subjectInternal Exposurept_PT
dc.subjectHBM4EUpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.titleHuman biomonitoring in health risk assessment in Europe: current practices and recommendations for the futurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.endPage737pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage727pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume222pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameAlvito
person.familyNameTeles Martins
person.familyNameAssunção
person.familyNameSilva
person.givenNameHenriqueta
person.givenNamePaula
person.givenNameCarla
person.givenNameRicardo
person.givenNameMaria Joao
person.identifier157627
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person.identifier.ciencia-idC419-FFAA-27E1
person.identifier.ciencia-id5B1D-9EB4-E1D4
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0001-8396-1357
person.identifier.orcid0000-0001-7930-2914
person.identifier.orcid0000-0002-4375-0456
person.identifier.orcid0000-0002-6060-0716
person.identifier.ridB-6977-2014
person.identifier.ridE-2738-2014
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id8590147800
person.identifier.scopus-author-id56330129500
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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