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How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets

2021-06-12Journal article Restricted access
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dc.contributor.authorMoreira, Luciana
dc.contributor.authorCosta, Carla
dc.contributor.authorPires, Joana
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorFraga, Sónia
dc.date.accessioned2022-02-01T16:18:56Z
dc.date.available2022-02-01T16:18:56Z
dc.date.issued2021-06-12
dc.description.abstractEvidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health.pt_PT
dc.description.sponsorshipThis work was supported by the NanoBioBarriers project (PTDC/MED-TOX/31162/2017), co-financed by the Operational Program for Competitiveness and Internationalization (POCI) through European Regional Development Funds (FEDER/FNR) and through national funds by the Portuguese Foundation for Science and Technology (FCT). Thanks are also due to FCT/MCTES for the financial support to EPIUnit (UIDB/04750/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMutat Res Rev Mutat Res. Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12. Reviewpt_PT
dc.identifier.doi10.1016/j.mrrev.2021.108385pt_PT
dc.identifier.issn1383-5742
dc.identifier.urihttp://hdl.handle.net/10400.18/7908
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S1383574221000223?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEpigeneticspt_PT
dc.subjectNanomaterialspt_PT
dc.subjectIn vitropt_PT
dc.subjectIn vivopt_PT
dc.subjectEpigenetic inheritancept_PT
dc.subjectHuman healthpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHow can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targetspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-TOX%2F31162%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.citation.startPage108385pt_PT
oaire.citation.titleMutation Research - Reviewspt_PT
oaire.citation.volume788pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1370de00-d228-47a7-8aed-320831dc4dcd
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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