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COVID-19 vaccine effectiveness among healthcare workers: a hospital-based cohort study

2023-05-02Journal article Open access
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dc.contributor.authorGaio, Vânia
dc.contributor.authorSantos, Ana João
dc.contributor.authorAmaral, Palmira
dc.contributor.authorFaro Viana, João
dc.contributor.authorAntunes, Isabel
dc.contributor.authorPacheco, Vânia
dc.contributor.authorPaiva, Artur
dc.contributor.authorPinto Leite, Pedro
dc.contributor.authorAntunes Gonçalves, Lígia
dc.contributor.authorAraújo, Lucília
dc.contributor.authorSilva, Adriana
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorKislaya, Irina
dc.contributor.authorNunes, Baltazar
dc.contributor.authorMachado, Ausenda
dc.date.accessioned2024-01-04T15:47:52Z
dc.date.available2024-01-04T15:47:52Z
dc.date.issued2023-05-02
dc.description.abstractObjectives: Healthcare workers (HCWs) were the first to be prioritised for COVID-19 vaccination. This study aims to estimate the COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 symptomatic infection among HCWs in Portuguese hospitals. Design: Prospective cohort study. Setting and participants: We analysed data from HCWs (all professional categories) from three central hospitals: one in the Lisbon and Tagus Valley region and two in the central region of mainland Portugal, between December 2020 and March 2022. VE against symptomatic SARS-CoV-2 infection was estimated as one minus the confounder adjusted HRs by Cox models considering age group, sex, self-reported chronic disease and occupational exposure to patients diagnosed with COVID-19 as adjustment variables. Results: During the 15 months of follow-up, the 3034 HCWs contributed a total of 3054 person-years at risk, and 581 SARS-CoV-2 events occurred. Most participants were already vaccinated with a booster dose (n=2653, 87%), some are vaccinated with only the primary scheme (n=369, 12.6%) and a few remained unvaccinated (n=12, 0.4%) at the end of the study period. VE against symptomatic infection was 63.6% (95% CI 22.6% to 82.9%) for HCWs vaccinated with two doses and 55.9% (95% CI -1.3% to 80.8%) for HCWs vaccinated with one booster dose. Point estimate VE was higher for individuals with two doses taken between 14 days and 98 days (VE=71.9%; 95% CI 32.3% to 88.3%). Conclusion: This cohort study found a high COVID-19 VE against symptomatic SARS-CoV-2 infection in Portuguese HCWs after vaccination with one booster dose, even after Omicron variant occurrence. The small sample size, the high vaccine coverage, the very low number of unvaccinated individuals and the few events observed during the study period contributed to the low precision of the estimates.pt_PT
dc.description.sponsorshipThe data of the study were originally collected as part of the project ‘Developing an infrastructure and performing vaccine effectiveness studies for COVID-19 vaccine in the EU/EEA’ (Contract ECD.11486 Lot3 (HCW) and amendment Nº ECD.11486), and the Enhanced laboratory support to perform assessment of vaccine effectiveness against SARS-CoV-2 infection (ECD.12175) and the ‘Vaccine Effectiveness, Burden and Impact Studies (VEBIS) of COVID-19 and Influenza’, funded by the European Centre for Disease Prevention and Control through a service contract with Epiconcept (ECD.12609).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMJ Open. 2023 May 2;13(5):e068996. doi: 10.1136/bmjopen-2022-068996pt_PT
dc.identifier.doi10.1136/bmjopen-2022-068996pt_PT
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10400.18/8851
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://bmjopen.bmj.com/content/13/5/e068996.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectHealthcare Workerspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectPortugalpt_PT
dc.titleCOVID-19 vaccine effectiveness among healthcare workers: a hospital-based cohort studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPagee068996pt_PT
oaire.citation.titleBMJ Openpt_PT
oaire.citation.volume13pt_PT
person.familyNameGaio
person.familyNameCarvalho da Silva Santos
person.familyNameMatias Dias
person.familyNameKislaya
person.familyNameNunes
person.familyNameMachado
person.givenNameVânia
person.givenNameAna João
person.givenNameCarlos
person.givenNameIrina
person.givenNameBaltazar
person.givenNameAusenda
person.identifier.ciencia-idA71A-17AF-30C7
person.identifier.ciencia-id7E12-E842-1216
person.identifier.ciencia-id6311-6117-ADEB
person.identifier.ciencia-idA815-4295-F91D
person.identifier.ciencia-idAB11-AD48-A8DF
person.identifier.ciencia-id1217-6076-5D88
person.identifier.orcid0000-0001-7626-4991
person.identifier.orcid0000-0003-0556-5513
person.identifier.orcid0000-0002-0206-5874
person.identifier.orcid0000-0001-5772-2416
person.identifier.orcid0000-0001-6230-7209
person.identifier.orcid0000-0002-1849-1499
person.identifier.ridI-6335-2012
person.identifier.scopus-author-id56080468200
person.identifier.scopus-author-id23103292400
person.identifier.scopus-author-id56442728800
person.identifier.scopus-author-id9133723200
rcaap.embargofctAcesso de acordo com a página web do editorpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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