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Cellular and Molecular Toxicity of Iron Oxide Nanoparticles

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dc.contributor.authorLaffon, Blanca
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorCosta, Carla
dc.contributor.authorBrandão, Fátima
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2019-03-25T16:58:13Z
dc.date.available2019-03-25T16:58:13Z
dc.date.issued2018
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042468/
dc.description.abstractIron oxide nanoparticles (ION) have attracted much attention because of their particular physico-chemical properties, including superparamagnetism. These features make them suitable for many purposes and several interesting biomedical applications, such as to increase contrast in magnetic resonance imaging (MRI), as drug delivery systems and as hyperthermia agents. However, they have also shown to be easily accumulated in diverse tissues and induce toxicity at different levels. This chapter reviews the different cellular and molecular effects induced by ION reported from in vitro studies with human and non-human cell lines. Those effects are mainly dependent on ION type and concentration, time of exposure, presence and nature of coating, and cell type evaluated. They include decreases in viability, plasmatic membrane disruption, oxidative damage, mitochondrial alterations, cell cycle impairments, cytoskeleton disruption, cell death, and alterations in cell motility, and in cell integrity. Despite these negative effects, the numerous advantages of ION together with their promising applications in biomedicine, make it necessary to clearly define their toxicity in order to discard potential health risks and to reach optimal benefits of their use.pt_PT
dc.description.sponsorshipThis work was supported by Xunta de Galicia (grant number ED431B 2016/013) and the projects NanoToxClass (ERA-SIINN/001/2013) funded by FCT/MCTES (PIDDAC) and co-funded by the European Regional Development Fund (ERDF) through the COMPETE Programme, and CERASAFE (SIINN/0004/2014) funded by FCT (national funds of MES) and co-funded by the European Union (ERA-NET SIINN programme). V. Valdiglesias was supported by a Xunta de Galicia postdoctoral fellowship (reference ED481B 2016/190-0). N. Fernández-Bertólez was supported by an INDITEX-UDC fellowship. F. Brandão was supported by the grant SFRH/BD/101060/2014, funded by FCT (financing subsided by national fund of MES).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAdv Exp Med Biol. 2018;1048:199-213. doi: 10.1007/978-3-319-72041-8_12pt_PT
dc.identifier.doi10.1007/978-3-319-72041-8_12pt_PT
dc.identifier.issn0065-2598
dc.identifier.urihttp://hdl.handle.net/10400.18/6301
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007%2F978-3-319-72041-8_12pt_PT
dc.subjectIron oxide nanoparticlespt_PT
dc.subjectCell Cyclept_PT
dc.subjectCell Deathpt_PT
dc.subjectCell Membranept_PT
dc.subjectCell Movementpt_PT
dc.subjectCell Survivalpt_PT
dc.subjectContrast Mediapt_PT
dc.subjectDrug Delivery Systemspt_PT
dc.subjectHumanspt_PT
dc.subjectMagnetite Nanoparticlespt_PT
dc.subjectAnimalspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleCellular and Molecular Toxicity of Iron Oxide Nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage213pt_PT
oaire.citation.startPage199pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
oaire.citation.volume1048pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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