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Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal

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dc.contributor.authorGuiomar, Raquel
dc.contributor.authorPereira da Silva, Susana
dc.contributor.authorConde, Patrícia
dc.contributor.authorCristóvão, Paula
dc.contributor.authorMaia, Ana Carina
dc.contributor.authorPechirra, Pedro
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorNunes, Baltazar
dc.contributor.authorMilho, Luís
dc.contributor.authorCoelho, Ana Paula
dc.contributor.authorFernandes, Aida
dc.contributor.authorCaseiro, Paula
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorCorreia, Lurdes
dc.contributor.authorPereira-Vaz, João
dc.contributor.authorAlmeida, Sofia
dc.contributor.authorBranquinho, Paula
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorViseu, Regina
dc.contributor.authorPeres, Maria João
dc.contributor.authorSanches, Raquel
dc.contributor.authorDantas, Filipa
dc.contributor.authorFreitas, Ludovina
dc.contributor.authorAndrade, Graça
dc.contributor.authorMaurílio, Manuel
dc.contributor.authorCaldeira, Filomena
dc.contributor.authorCabral Veloso, Rita
dc.contributor.authorMota-Vieira, Luísa
dc.contributor.authorSoares, Marta
dc.contributor.authorCouto, Ana Rita
dc.contributor.authorBruges-Armas, Jácome
dc.contributor.authorMouro Pinto, Rita
dc.contributor.authorSobrinho Simões, Joana
dc.contributor.authorRosário Costa, Maria
dc.contributor.authorGuimarães, João Tiago
dc.contributor.authorMartins, Luís
dc.contributor.authorCunha, Mário
dc.date.accessioned2017-07-03T13:12:01Z
dc.date.available2018-04-12T00:30:12Z
dc.date.issued2017
dc.descriptionEm colaboração com a Rede Portuguesa de Laboratóros para o Diagnóstico da Gripept_PT
dc.description.abstractIntroduction: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. Materials and methods: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. Results: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2–43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3–33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing crossprotection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65 years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7–41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. Conclusions: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.pt_PT
dc.description.sponsorshipThis work was supported by the National Institute of Health Doutor Ricardo Jorge, IP Lisbon, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationVaccine. 2017 Apr 11;35(16):2092-2099. doi: 10.1016/j.vaccine.2017.02.019. Epub 2017 Mar 18.pt_PT
dc.identifier.doihttp://dx.doi.org/10.1016/j.vaccine.2017.02.019pt_PT
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/10400.18/4730
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0264410X1730213Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectInfluenzapt_PT
dc.subjectCross-protectionpt_PT
dc.subjectSeroprevalencept_PT
dc.subjectSeroepidemiologic Studiespt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleCross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleVaccinept_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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