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Transforming Growth Factor-b1 polymorphism is not associated with chronic graft disease: evidence from a meta-analysis
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Autores
Orientador(es)
Resumo(s)
Kidney transplantation has been recognised as the optimal
treatment choice for most end stage renal disease patients and the
increase of allograft survival rates is achieved through the
refinement of novel immunosuppressive agents. Chronic Graft
Disease (CGD) is a multifactorial process that likely includes a
combination of immunological, apoptotic and inflammatory factors.
The application of individualised immunosuppressive therapies will
also depend on the identification of risk factors that can influence
chronic disease. Despite being the subject of several independent
studies, investigations of the relationship between transforming
growth factor-b1 (TGF-b1) polymorphisms and kidney graft
outcome continue to be plagued by contradictory conclusions.
Descrição
Palavras-chave
Kidney Transplantation Chronic Graft Disease
Contexto Educativo
Citação
Editora
John Wiley and Sons