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Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children

2022-06-16Journal article Open access
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dc.contributor.authorGouveia, Catarina
dc.contributor.authorSubtil, Ana
dc.contributor.authorNorte, Susana
dc.contributor.authorArcangelo, Joana
dc.contributor.authorSantos, Madalena Almeida
dc.contributor.authorCorte-Real, Rita
dc.contributor.authorSimões, Maria João
dc.contributor.authorCanhão, Helena
dc.contributor.authorTavares, Delfin
dc.date.accessioned2023-02-28T14:05:03Z
dc.date.available2023-02-28T14:05:03Z
dc.date.issued2022-06-16
dc.descriptionThis article belongs to the Special Issue Kingella kingae: Virulence Factors, Clinical Disease, and Diagnostics.pt_PT
dc.description.abstract(1) Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age > 6 months ≤ 2 years, apyrexy and CRP ≤ 100 mg/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767-0.955) K. kingae SA from typical pathogens. (4) Conclusions: Age > 6 months ≤ 2 years, apyrexy and PCR ≤ 100 mg/L were the main predictive factors to distinguish K. kingae from pyogenic SA < 5 years. These data need to be validated in a larger study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMicroorganisms. 2022 Jun 16;10(6):1233. doi: 10.3390/microorganisms10061233.pt_PT
dc.identifier.doi10.3390/microorganisms10061233pt_PT
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/10400.18/8538
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/10/6/1233pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectKingella kingaept_PT
dc.subjectAcute Septic Arthritispt_PT
dc.subjectPyogenic Infectionspt_PT
dc.subjectDiagnosticspt_PT
dc.subjectAcute Septic Arthritispt_PT
dc.subjectChildrenpt_PT
dc.subjectPortugalpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleDistinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage1233pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume10pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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